The INoVA uses entity recognition models to extract models and associated readouts (outcomes) from sentences in PubMed abstracts. The following definitions are used for these entities:
Model
The experimental setup (e.g. wound healing assay, Irwin test) used to measure an outcome, or the system in which an outcome is being measured (e.g. CACO-2 cells, the liver, ob/ob mice). The following model types are included: In vitro, in vivo, ex vivo, in silico and in chemico.
Readout
What is being measured in the model. Both quantitative measures and qualitative outcomes are being retrieved.
Searching and filtering
The INoVA hub uses free text searches as well as pre-defined filtering options to guide the user in retrieving relevant publications. The various options are described below. Multiple filters and/or free text searches can be used to define your search.
Free text search
Free text searches are available for the model name, readout and species.
By typing in the name and clicking on "apply", a substring search is performed on all models and readouts in our platform.
For species, a generative AI mapping has been performed on the sentence level.
Therefore, the species has been inferred from the model and/or sentence.
To correctly handle abbreviations, an attempt is made to map a search term on its full name if an abbreviation is being used, and vice versa, abbreviations of a full name are included when possible.
Boolean queries are currently not supported in search.
Predefined filters
The models recognized have been mapped to model parameters whenever possible.
This mapping has been performed by a generative AI model on a contextual level.
This means that the whole sentence has been used to classify the models to the predefined parameters.
The model parameters can be used either to query the INoVA hub data, or to filter results.
To use the filters, select a parameter from the pulldown menu and click the apply button.
When multiple model parameters are used, the AND logic is being performed.
The following model parameters are available:
System type, e.g. in vitro, in vivo, in silico
System format, e.g. bioengineered system, organism
Inducer type, e.g. chemical, diet, genetic engineering
Health domain, e.g. cardiovascular disease
Organ system, e.g. heart, liver
For the organ system parameter, two levels of granularity are offered.
The second level offers a more detailed.
Please note that the model parameters are set independent from each other.
The user is responsible for making meaningful intersections of the parameter values.
Dynamic data
The information available in the INoVA hub interface is updated daily and contains all PubMed abstract data from the year 2015 onwards.
Selection and Download
To select and download PMIDs for further analysis, tick the box of the publication and click the download button.
The number of downloads is limited to a maximum of 100 records.
The MCS generally remain an out-of-pocket expense.
MCSs are an effective option for myopia control without relevant side effects, particularly in younger children, rapid progression or with genetic risk factors.
The prevalence of myopia is postulated to be rising worldwide, along with the risk of secondary complications, such as maculopathy; however, the evidence for this remains inconclusive, particularly for Europe.
Participants read two or three sentence passages in which a homograph appeared in the first sentence and the disambiguating information was in the last.
Characteristics of and Clinical Criteria for Oropouche Virus Disease, United States, May 2024-January 2025.
In total, 65 case-patients reported > 5 symptoms, commonly fever (94 %), headache (83 %), and myalgia (78 %).
Among patients with Oropouche virus disease, 50 (48 %) were female and 54 (52 %) male; median age was 52 years.
We assessed characteristics of patients with Oropouche virus disease (n = 104), compared symptoms with patients who tested negative (n = 266), and evaluated the sensitivity and specificity of symptom combinations.
In response to the 2024-2025 Oropouche virus outbreak in the Americas, the Centers for Disease Control and Prevention initiated testing for suspected cases in the United States.
A component analysis of the Resilience Education Program: A Tier 2 intervention for internalizing behavior concerns.
Schools were randomly assigned to one of three experimental conditions.
Through a component analysis of REP, findings suggested that students in the CBI + CICO condition demonstrated practically significant decreases in students ' internalizing behavior concerns than the CBI + RF and CBI + CICO + RF conditions.
REP is a three-part intervention that incorporates small-group cognitive-behavioral instruction (CBI), a modified check-in/check-out reinforcement-based mentorship program (CICO), and resilient families (RF), a parent skills training program.
Participants included 57 students (ages 10-14 years old) from six urban schools in the midwestern United States.
The current pilot study examines student outcomes associated with receipt of the Resilience Education Program (REP), a Tier 2 school-based intervention designed to support students with internalizing behavior concerns.
Implementation and social validity data indicated that school mental health professionals and educators could implement and adapt REP, finding REP to be acceptable and feasible.
Latent classes of family vulnerability and associations with parental functioning during the COVID-19 pandemic.
During the pandemic, families in the complex risk and contextual risk groups reported significantly higher parenting stress and poorer mental health than well-adapted families, whereas low collaboration and interpersonal risk groups were not consistently linked to poorer outcomes.
Across both family structures, three distinct vulnerability classes emerged: a well-adapted group (low risk) and two elevated-risk groups differing by domain.
Among families living together, elevated-risk classes included an interpersonal risk group and a contextual risk group.
Among families living apart, the elevated-risk classes included a low collaboration group and a complex risk group characterized by cumulative vulnerabilities.
Training in vigilant care for parents of juvenile offenders: A randomized controlled trial.
Participants were 264 parents of adolescents (12-18 years old) who were referred to the Israeli Juvenile Probation Service for committing legal offenses.
Multilevel models revealed significant differences between treatment arms such that parents in PVC had significantly greater increases in parental knowledge and anchoring following treatment than parents in treatment as usual.
Parents were randomly assigned to receive either group PVC training or treatment as usual, which consisted of adolescent-based treatment with two parent group sessions.
Parental Vigilant Care (PVC) is a treatment approach that targets parenting factors associated with reduced risk behavior in adolescents.
The findings suggest that training in PVC may improve parenting factors associated with risk reduction among juvenile offenders and may carry additional benefits in terms of treatment retention.
Training in vigilant care for parents of juvenile offenders: A randomized controlled trial.
Moderating effect of parent self-esteem and depression on links between child behavior and interparental communication.
Results were explored separately for mothers and fathers.
Parents of children with chronic disruptive behaviors consistently report greater interparental discord than parents of children without such concerns.
Findings highlight the synergistic pattern of parenting self-esteem and depressive symptoms, particularly in fathers, and suggest that these parent characteristics may help identify families who are more susceptible to discordant partner communication under child-driven stress.
For mothers, disruptive child behavior predicted more negative communication among those with high depressive symptoms and low efficacy.
For fathers, several three-way interactions emerged, including stronger links between disruptive child behavior and more negative and less positive communication among those with high depressive symptoms and low efficacy or satisfaction.
The present study examines 90 parent couples randomly assigned to interact with a 9- to 12-year-old confederate exhibiting either typical or disruptive behaviors.
These families also report lower parenting self-esteem and higher rates of depression, both of which may contribute to poor partner communication.
"How do you recognize the little wins": Reframing success in individual placement and support from the perspective of program clients and service providers.
We engaged Individual Placement and Support program clients, service providers, and clinical/administrative staff (n = 50) in a Delphi study and subsequent community session.
`` How do you recognize the little wins '': Reframing success in individual placement and support from the perspective of program clients and service providers.
Suction versus traditional ureteral access sheaths in retrograde intrarenal surgery: an updated systematic review and meta-analysis of stone-free rates and complications.
Five databases were searched from inception to March 2026 for comparative studies of S-UAS versus traditional sheaths (T-UAS) in adult RIRS (PROSPERO CRD420251164154).
Preadolescent psychosocial maladjustment in children who exhibited different developmental patterns of co-occurring externalizing behaviors during the preschool years.
The co-occurrence of externalizing behaviors (EBs) in school-aged children is associated with long-term homotypic (similar) and heterotypic (diverse) psychosocial difficulties.
Preschoolers with a high co-occurrence pattern encompassing all three EBs showed the poorest psychosocial adjustment across all 14 outcomes in the four maladjustment domains.
They underscore the importance of early manifestations of EBs and highlight that the multiple co-occurring EBs observed in preadolescents originate from similar patterns observable during the preschool years.
Six high-trajectory classes, identified with latent growth modeling, were used as longitudinal indicators of EBs and compared to a reference class of children with low or moderate trajectories across all EBs, controlling for internalizing problems and other confounders.
Preadolescent psychosocial maladjustment in children who exhibited different developmental patterns of co-occurring externalizing behaviors during the preschool years.
Parental racial trauma and Black preschoolers' socioemotional health: Socialization processes as risk and protective factors.
This study examines whether Black parents ' racial trauma symptoms are associated with internalizing and externalizing behaviors in preschool-aged children and whether emotion and racial socialization parenting practices moderate these associations.
Participants were 168 Black parents (Mage = 34.03) of children ages 3-5 years (57.7 % boys) living in New York City.
Potentially psychologically traumatic event exposures among Royal Canadian Mounted Police during the first year of service.
Participants reported higher prevalence for almost all PPTE types than previously reported by the Canadian general population (all ps <.001) but lower prevalences for all PPTE types than previously reported by longer serving RCMP (all ps <.001).
RCMP (n = 181; 72.8 % male) participating in the RCMP Longitudinal Posttraumatic Stress Disorder Study self-reported mental health disorder symptoms and PPTE exposures experienced during their first year of service.
The present study examines PPTE exposures experienced by Royal Canadian Mounted Police (RCMP) during their first year of service and examines associations with anxiety-, depressive-, and trauma-related mental health disorders.
Potentially psychologically traumatic event exposures among Royal Canadian Mounted Police during the first year of service.
After 1 year of service, participants reported an average of ∼39 PPTE exposures across ∼ 6 PPTE types.
Individual, interpersonal, and socioeconomic predictors of divorce: A 12-year prospective study.
The current analyses address this gap through a study of 368 different-sex newlywed couples who provided data on six clusters of predictors within 6 months of marriage: relationship satisfaction for each spouse, individual vulnerabilities for each spouse, couples ' adaptive behavior, and socioeconomic risk.
Exploring vulnerabilities and their effects promises to deepen understanding of how relationships develop and deteriorate and can clarify boundary conditions of behavioral models of divorce.
Over the next 12 years, 39 % of couples divorced.
Structured variation in daily life experience within and across individuals.
Healthy adults (N = 97) completed 14 days of biologically triggered experience sampling.
Here we leverage a powerful alternative approach to examine variability in emotional experience by sampling multimodally from individuals across a variety of contexts throughout their daily life and employing unsupervised machine learning to discover reliable, person-specific, multimodal patterns of experience.
Participants wore mobile cardiac monitors for 8 hr/day and reported their current valence, arousal, primary activity (e.g., relaxing), social context (e.g., alone), and emotional experience (via free report) when prompted.
Structured variation in daily life experience within and across individuals.
Human experience varies across contexts and individuals.
Reducing risky sex for young women in underserved settings: Motivational interviewing versus sex education.
For consistent condom use, DEC outperformed MI for Hispanic participants.
Future studies should include qualitative methods to determine why Hispanic young women may be particularly responsive to sex education for condom use.
Underserved settings may consider using MI, perhaps with sex education to enhance condom use among Hispanic young women.
Participants (N = 272, ages 14-21 years, 35 % White, 21 % Black, 44 % another racial group, 44 % Hispanic, 57 % received public assistance), recruited from the United States, were randomized to MI or DEC. Data, gathered via interview, urine sample, and vaginal swab, were analyzed with logistic regression and generalized estimating equations.
Compared to DEC, MI was efficacious in reducing behaviors putting young women at risk for unintended pregnancy and sexually transmitted infections (e.g., condomless sex with substance use) and was efficacious for reducing pregnancy for racially (|B| = 1.62, p =.01) and ethnically (|B| = 3.30, p =.01) minoritized participants.
This study tested motivational interviewing (MI) with feedback versus didactic education counseling (DEC) to reduce unintended pregnancy and sexually transmitted infections among young women in underserved settings (e.g., alternative schools).
Reducing risky sex for young women in underserved settings: Motivational interviewing versus sex education.
The dual-level dynamics of moral incongruence: A multilevel analysis of problematic pornography use.
Using a multilevel modeling approach, results at the between-person level indicated that moral disapproval was negatively associated with use frequency but positively associated with PPU and that the interaction of disapproval and frequency was a significant predictor of PPU.
Data were collected over five waves (2 years) from a large community sample of American adults (N = 4,363); analyses were restricted to those who contributed at least one active-use wave (N = 7,512 person-waves from 2,903 individuals).
Multidimensional loss chasing among online sports gamblers: Assessing the moderating effects of starting behaviors on harm prediction.
In terms of the VSE outcome, loss chasing effects were more likely to be significant, or otherwise stronger, among bettors with initially high bet size but not among bettors with initially high number of bets.
Multidimensional loss chasing among online sports gamblers: Assessing the moderating effects of starting behaviors on harm prediction.
Prevalence of generalized joint hypermobility, hypermobility spectrum disorders and Ehlers-Danlos syndrome: systematic review and meta-analysis.
From the meta-analysis the pooled prevalence across included studies of GJH in females were 9.5 % (95 % CI: 5.5; 15.8) with an I² of 95.5 % and 5.2 % (95 % CI: 3.0; 9.0) in males with an I² of 94.8).
Only one single study assessed HSD and hypermobile Ehlers-Danlos syndrome, hEDS in individuals aged 18-50 years and reported a prevalence of HSD of 38 % in females and 39 % in males, and the prevalence of hEDS as 2 % in females and 0 % in males.
The evidence base for the age group 51 and older was insufficient for a robust estimate.
It's not in your HEADSS: Mental health screening in adolescent primary care visits.
Medical records (N = 2,255) were coded to assess HEADSS administration by medical and behavioral health clinicians as part of well child visits for youth aged 12 and older (Mage = 13.97) in a large pediatric primary care clinic.
Screening and surveillance of mental health concerns and risky behavior in primary care clinics leads to increased identification and treatment.
Effects of a nutraceutical multicomponent supplement (Vertilev®) in older people with chronic dizziness: a prospective, open-label, single-arm multicenter study.
Patients received Vertilev® (Levante Srl) 2 tablets/day for 90 days and were assessed at baseline (T0), and after 30, 60, and 90 days (T30, T60, and T90, respectively).
Effects of a nutraceutical multicomponent supplement (Vertilev®) in older people with chronic dizziness: a prospective, open-label, single-arm multicenter study.
During the 90-day supplementation period, significant and progressive improvements were observed in dizziness-related disability, postural stability, and gait performance in elderly patients with chronic dizziness.
This prospective, open-label, single-arm, multicenter study evaluated the potential effects and tolerability of a multicomponent nutraceutical supplement (Vertilev®; Levante Srl, Florence, Italy) in patients with chronic dizziness.
Outcome measures included the Dizziness Handicap Inventory (DHI) total score and subscales (primary outcome), Visual Analog Scale (VAS) for dizziness self-assessment, VAS for anxiety/mood, Tinetti Performance-Oriented Mobility Assessment (POMA), and Timed Up and Go (TUG) test.
This study included 45 patients with chronic dizziness (aged ≥65 years; 20 males, 25 females).
Forty of the 45 enrolled patients (88.9 %) completed the T90 assessment; 5 patients withdrew from the study before the assessment.
Chronic dizziness and postural instability are highly prevalent in the elderly population, affecting 10-30 % of individuals over 65, substantially impairing quality of life and increasing fall risk.
No control or placebo group was included; this was a single-arm pre-post study.
The excellent tolerability profile supports further investigation of Vertilev® (Levante Srl) as a nutraceutical option in the management of presbystasis and chronic vestibular disorders in older people.
How hearing children of deaf parents navigate deafness-related stigma.
Optimal dosing and timing of ruxolitinib remains unclear.Case ReportWe describe four allo-HCT recipients who required early tacrolimus discontinuation due to neurotoxicity (n = 2) or nephrotoxicity (n = 2) and were transitioned to ruxolitinib for GVHD prophylaxis.
All four patients experienced resolution of their tacrolimus-related toxicity, and no acute or chronic GVHD events were observed at last follow-up.
ATMLP regulates MDVs mediated inflammation induced by radiotherapy in lung cancer.
To address this, cell lines with ATMLP overexpression and knockdown were created using gene editing techniques, and Western blot, immunofluorescence and trans-well co-culture were used to explore the role of mitochondria-derived vesicles (MDVs) in mediating radiotherapy-induced inflammation, as well as the effects of ATMLP, DRP-1 and PGAM5 on MDVs.
The NS4B A119T mutation of dengue virus 2 confers adaptation to mammalian cells and increased pathogenicity in AG129 mice.
Mouse-adapted dengue virus type 2 (DENV2), designated the AG-P10 strain, was established through serial blind passages between AG129 mice and mosquito C6/36 cells.
In vitro characterization of the AG-P10 strain demonstrated significantly enhanced viral replication and larger focus formation in mammalian Vero and A549 cells but not in mosquito-derived C6/36 cells, suggesting host-specific adaptation.
Through an analysis of recombinant viruses, we determined that the A119T mutation alone is sufficient to confer enhanced pathogenicity in AG129 mice and increased viral replication in Vero and A549 cells, suggesting its potential role in viral adaptation and pathogenesis.
Whole-genome sequencing of the AG-P10 strain identified two nonsynonymous mutations, A119T in NS4B and E802Q in NS5.
Compared with the parental strain INDIA/09-74, the AG-P10 strain exhibited increased virulence in AG129 mice, leading to rapid body weight loss and earlier mortality.
The NS4B A119T mutation of dengue virus 2 confers adaptation to mammalian cells and increased pathogenicity in AG129 mice.
The DENV2 with the A119T mutation, as well as the AG-P10 strain, thus provides a robust animal model for developing antiviral therapeutics and vaccines against DENV and for investigating the molecular mechanisms governing DENV2 replication and virulence.
Cardiac Autonomic Dysfunction in Diabetic Highlander and Lowlander Populations of Nepal Assessed by Heart Rate Variability.
The present study aims to compare cardiac autonomic function in diabetic highlanders vs diabetic lowlanders of Nepal using heart rate variability (HRV).MethodsA cross-sectional study was performed on a total of 128 patients with type 2 diabetes mellitus (T2DM), including 64 native highlanders residing above 2500 m (Phaplu, Solukhumbu district, Nepal) and 64 native lowlanders below 500 m (Biratnagar, Morang District, Nepal).
High-altitude dwellers exhibit physiological adaptations that may regulate autonomic function.
Comparative statistical analysis was conducted using independent t tests and Mann-Whitney U tests.ResultsIn time-domain HRV parameters, diabetic highlanders showed significantly higher SDNN (88.9 [ 48.5-97.2 ] ms vs 28.7 [ 20.2-43.1 ] ms; P <.001) and increased RMSSD (64.9 [ 35.1-92.3 ] ms vs 21.6 [ 14.3-38.3 ] ms; P <.001) compared to lowlanders.
Likewise, in frequency-domain HRV analysis, as compared to diabetic lowlanders, diabetic highlanders revealed significantly increased HF power (317.6 [ 96.5-869.2 ] ms2 vs 86.1 [ 29.7-314.0 ] ms2; P <.001) and lower LF/HF ratio (0.4 [ 0.2-1.1 ] vs 1.2 [ 0.9-3.4 ]; P <.001) demonstrating relatively better autonomic balance.ConclusionHighlanders with T2DM exhibit relatively preserved cardiac autonomic balance compared to diabetic lowlanders, indicating that chronic exposure to high altitude influences diabetes-related autonomic dysfunction.
Cardiac Autonomic Dysfunction in Diabetic Highlander and Lowlander Populations of Nepal Assessed by Heart Rate Variability.
These findings highlight the importance of considering geographical and environmental factors during management and risk assessment of diabetic individuals in Nepal.
Quercetin combined with cinnamaldehyde ameliorates insulin resistance via modulation of the G protein-coupled receptor 120/p38 mitogen-activated protein kinase/Kruppel-like factor 15 signaling pathway.
To validate the underlying mechanism, GPR120 and KLF15 overexpression and KLF15 silencing were performed in adipocytes.ResultsIn palmitic acid-induced 3T3-L1 adipocytes, quercetin and cinnamaldehyde alone enhanced glucose consumption, downregulated GPR120 and p-p38 MAPK expressions, and upregulated KLF15 expression compared with those in the insulin resistance model group.
In rat insulin resistance models, the combination significantly improved glucose tolerance and insulin sensitivity; reduced serum lipid and blood glucose levels (p < 0.05) levels; and regulated the expressions of GPR120, p-p38 MAPK, and KLF15 in adipose tissue more effectively than single-agent treatment (p < 0.05).ConclusionThe combination of quercetin and cinnamaldehyde exerted an enhanced beneficial effect in improving insulin resistance, which was associated with modulation of the GPR120/p38 MAPK/KLF15 signaling pathway, providing a potential therapeutic strategy for insulin resistance-related diseases.