The INoVA uses entity recognition models to extract models and associated readouts (outcomes) from sentences in PubMed abstracts. The following definitions are used for these entities:
Model
The experimental setup (e.g. wound healing assay, Irwin test) used to measure an outcome, or the system in which an outcome is being measured (e.g. CACO-2 cells, the liver, ob/ob mice). The following model types are included: In vitro, in vivo, ex vivo, in silico and in chemico.
Readout
What is being measured in the model. Both quantitative measures and qualitative outcomes are being retrieved.
Searching and filtering
The INoVA hub uses free text searches as well as pre-defined filtering options to guide the user in retrieving relevant publications. The various options are described below. Multiple filters and/or free text searches can be used to define your search.
Free text search
Free text searches are available for the model name, readout and species.
By typing in the name and clicking on "apply", a substring search is performed on all models and readouts in our platform.
For species, a generative AI mapping has been performed on the sentence level.
Therefore, the species has been inferred from the model and/or sentence.
To correctly handle abbreviations, an attempt is made to map a search term on its full name if an abbreviation is being used, and vice versa, abbreviations of a full name are included when possible.
Boolean queries are currently not supported in search.
Predefined filters
The models recognized have been mapped to model parameters whenever possible.
This mapping has been performed by a generative AI model on a contextual level.
This means that the whole sentence has been used to classify the models to the predefined parameters.
The model parameters can be used either to query the INoVA hub data, or to filter results.
To use the filters, select a parameter from the pulldown menu and click the apply button.
When multiple model parameters are used, the AND logic is being performed.
The following model parameters are available:
System type, e.g. in vitro, in vivo, in silico
System format, e.g. bioengineered system, organism
Inducer type, e.g. chemical, diet, genetic engineering
Health domain, e.g. cardiovascular disease
Organ system, e.g. heart, liver
For the organ system parameter, two levels of granularity are offered.
The second level offers a more detailed.
Please note that the model parameters are set independent from each other.
The user is responsible for making meaningful intersections of the parameter values.
Dynamic data
The information available in the INoVA hub interface is updated daily and contains all PubMed abstract data from the year 2015 onwards.
Selection and Download
To select and download PMIDs for further analysis, tick the box of the publication and click the download button.
The number of downloads is limited to a maximum of 100 records.
The resulting WS2 nanoscrolls demonstrate an enhancement in second-harmonic generation (SHG) exceeding 4 orders of magnitude (up to 1.4 × 104) compared to monolayers, accompanied by significant amplification of Raman scattering signals.
Setbacks to strengths: A scoping review of positive psychology constructs among veterans and service members with traumatic brain injury.
The majority of studies represent veterans (n = 42) who sustained a mild TBI more than 12 months before the study.
Setbacks to strengths: A scoping review of positive psychology constructs among veterans and service members with traumatic brain injury.
Positive psychology intervention studies among military personnel are sparse (n = 3).
Using Joanna Briggs Institute and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines, we identified English peer-reviewed studies published from 2000 to 2024 across four databases (MEDLINE, Embase, APA PsycInfo, and Web of Science) using search terms representing PPCs investigated among adults with military background and TBI.
This study conducted a scoping review of the current research on positive psychology constructs (PPCs) among military personnel with TBI.
Behavioral health provider training to enhance family partnerships.
Providers ' partnership with families of adults with serious mental health and other behavioral health conditions can be a powerful recovery tool.
Further development of training is needed to enhance the capacity of the workforce providing services to adults with behavioral health conditions to effectively include families, regardless of the specific intervention used.
The survey found that regardless of clinical background, most providers reported interest in receiving training specifically related to working with families of adults with behavioral health conditions.
Dual-Functional Potassium Citrate: Synergistic In Situ Carbon Filling and Activation toward Wood-Based Thick Carbon Electrodes with Enhanced Capacitive Performance.
Herein, we prepare high-mass-loading wood-based thick carbon electrodes using potassium citrate as a dual-functional modifier (chemical activator and in situ carbon precursor).
Electrical double-layer capacitors (EDLCs) and zinc-ion hybrid capacitors (ZHCs) are promising green energy storage devices, but their practical application is limited by low mass loading of traditional carbon electrodes, causing insufficient capacitance and low energy density.
Wood-derived carbon with vertical channels is ideal for thick electrode fabrication but suffers from a poor pore structure and low channel utilization.
Dual-Functional Potassium Citrate: Synergistic In Situ Carbon Filling and Activation toward Wood-Based Thick Carbon Electrodes with Enhanced Capacitive Performance.
This work provides a new strategy for designing high-mass-loading biomass-derived carbon thick electrodes and deepens the understanding of organic potassium salt modification for carbon materials.
Estimating a Physiological Lung Function Score and Biological Sex Using Pulmonary Function Tests and Machine Learning: Retrospective Study.
We retrospectively analyzed complete pulmonary function tests from 6392 healthy adults across 3 Mayo Clinic regions.
Age-stratified evaluation showed the overestimation of lung age in younger adults and underestimation in older adults.
Four models of increasing complexity were trained using gradient-boosted machines to predict chronological age and biological sex.
We hypothesized that a machine learning model could be trained to predict a person 's lung age and self-reported sex using pulmonary function test data.
Who benefits from autonomy? Action-state orientation moderates the effect of autonomy need satisfaction at work on employee well-being.
State-oriented employees seem to generally benefit from high levels of autonomy need satisfaction at work across contexts, whereas action-oriented employees appear to benefit most from autonomy need satisfaction at work when facing specific situational stressors that require them to unfold their self-regulatory abilities.
Action-oriented employees can easily draw on their integrated self, and thus their self-regulatory abilities, during stressful work situations, whereas state-oriented employees struggle to do so under work stress.
Therefore, we expect state-oriented employees to benefit more strongly from autonomy need satisfaction at work as a resource than action-oriented employees.
Both studies confirmed that practitioners should not assume all employees benefit equally from autonomy need satisfaction since personality matters.
Hybrid sequencing reveals incompleteness of the H37Rv reference genome and highlights lineage-specific genomic divergence in
Mycobacterium tuberculosis.
The Chinese laboratory-adapted H37Rv_CN strain differed by 145 SNPs, 49 InDels and 14 structural variants from the reference genome.
We performed hybrid sequencing to generate high-quality assemblies of a clinically isolated Beijing family strain (A2018772) and a Chinese laboratory-adapted H37Rv strain (H37Rv_CN).
When applied to transmission analysis of 3,359 Chinese Lineage 2 strains, the A2018772 as a reference genome demonstrated superior performance with higher mapping rates (99.52 % vs. 98.72 %) and coverage (99.73 % vs. 98.50 %) compared to H37Rv_ref.
The Beijing family clinical isolated strain A2018772 showed even greater divergence with 2,277 SNPs, 373 InDels and 219 structural variants compared to H37Rv_ref, with particular enrichment in PE/PPE genes and metabolic pathways.
This improved resolution resulted in fewer transmission clusters (273 vs. 285) at the 5-SNP threshold, indicating that H37Rv_ref consistently overestimates transmission events in Lineage 2-dominated populations.Conclusion.
Comprehensive genomic analysis revealed substantial differences between both studied strains and H37Rv_ref.
The impact of reference genome choice on transmission clustering was evaluated using a dataset of 3,359 M. tuberculosis Lineage 2 strains from China.Results.
Among these variations, a 9.2 kb deletion was prevalent in 89.7 % of 78 publicly available Lineage 2 genomes.
The Mycobacterium tuberculosis H37Rv reference genome (Lineage 4), sequenced in 1998, may be incomplete and inaccurate due to earlier technology.
Affective intensity of enacted stigma events and emotion regulation strategy use among sexual and gender minorities.
We used data from an ecological momentary assessment study of enacted stigma from a sample of 109 older adult sexual and gender minorities, a group that is largely underrepresented in research on enacted stigma.
An Exploration of Danish Forensic Hospital Staffs' Clinical Decision-Making about the Least Restrictive Alternative Principle.
This study investigates how Danish forensic hospital staffs perceive the least restrictive alternative principle and how these perceptions influence their perceptions of decision-making when choosing among restrictive interventions.
Previous studies identified that mental health staff have conflicting attitudes about which interventions are the least restrictive.
A combination of two focus groups with nine staff members and seven individual interviews (10 nursing staff, 6 medical staff) were conducted.
An Exploration of Danish Forensic Hospital Staffs ' Clinical Decision-Making about the Least Restrictive Alternative Principle.
Temporal cueing of conflict reduces congruency effects in the Eriksen flanker and Simon tasks.
Temporal cueing of conflict reduces congruency effects in the Eriksen flanker and Simon tasks.
However, for the Eriksen flanker task, this modulation was larger when the long rather than the short FP predicted conflict, whereas for the Simon task, this modulation was similar or, if any, larger for the short than the long conflict-predicting FP.
In Experiment 2, conflict effects were also reduced with conflict-predicting FPs in a confound-minimized four-choice version of the Eriksen flanker task, though effects were smaller and reached significance only in the Diffusion Model for Conflict task analyses.
Overall, these findings suggest that temporal cueing of conflict can enhance cognitive control in conflict tasks by strengthening distractor suppression, albeit in a manner that is partly specific to the conflict task.
Mean reaction time analyses revealed that conflict effects were generally reduced with conflict-predicting FPs in both tasks.
Previous studies have shown that congruency effects are often reduced when exogenous cues predict conflict between targets and distractors in conflict tasks.
To address this, we conducted two large-scale experiments (N = 270), supplementing mean performance analyses with diffusion modeling (Diffusion Model for Conflict tasks).
In Experiment 1, short and long foreperiods (FPs) were associated with high or low conflict probabilities in classical two-choice versions of the Eriksen flanker and Simon tasks.
Morphological Distinction of Supra-RPE Deposits in Idiopathic Full-Thickness Macular Holes.
In FD eyes deposit area correlated with postoperative changes in EZd and ELMd, whereas no such association was found in GD eyes.
ΔVA was significantly smaller in GD eyes (-0.40 vs. -0.65 logMAR, p < 0.001).
In this retrospective study 66 eyes from 66 patients with idiopathic FTMH undergoing vitrectomy with ILM peeling were analyzed.
GD identifies eyes with larger MHs and reduced likelihood of optimal postoperative functional recovery.
To investigate whether the morphology of supra-retinal pigment epithelial (RPE) deposits influences anatomical and functional outcomes in idiopathic full-thickness macular holes (FTMHs).
Supra-RPE deposits were segmented from en face OCT slabs.
Systematic Metabolic Engineering and Fermentation Optimization of
Yarrowia lipolytica for High-Yield Production of Scutellarin.
The resulting strain produced 1,184.24 mg/L in shake flasks; fed-batch fermentation in a 5-L bioreactor reached 6,370.39 mg/L, which is the highest microbial titer reported to date, with only 7.26 % byproduct.
Affordable GLP-1? When Digital Platforms Meet Policy Reform.
This study aimed to evaluate the clinical outcomes and safety of ultrasound-guided pulsed radiofrequency (PRF) targeting the mandibular nerve (V3) with adjunct low-dose perineural dexamethasone in patients with trigeminal neuralgia (TN).
We retrospectively analyzed 73 consecutive patients treated between April 2022 and August 2025.
Greater mother-infant synchrony predicts less positive emotion in infants at high levels of maternal anxiety.
However, the notion of synchrony as universally beneficial draws largely from studies involving mothers at low risk for psychopathology.
Greater mother-infant synchrony predicts less positive emotion in infants at high levels of maternal anxiety.
High levels of mother-infant neural synchrony in the first year of life are traditionally linked to positive socioemotional outcomes for infants, while low synchrony relates to more negative outcomes.
Theories of mothers as scaffolds for development suggest that synchrony with a dysregulated mother may be less beneficial for developing infants.
Spontaneous movements of preterm-born infants predict social competence and self-esteem at early school age: The mediating role of motor skills and maternal emotional availability.
These results highlight the significance of motor functioning in infancy and childhood for the socioemotional adjustment of preterm-born children.
Preterm-born infants face a heightened risk for socioemotional challenges.
One hundred six Israeli preterm-born infants (38.3 % girls; 20.70 % Arab) from middle-class families participated in the study.
Children 's motor skills were evaluated using a standard test, and mothers ' emotional availability was observed during mother-child play interactions.
At Time 1, when infants were at the corrected age of 11-22 weeks (M = 14.5 weeks, SD = 2.14), their spontaneous movements were assessed.
Processing speed deficits: A missing link in understanding individual variation in children's interval timing skills?
This suggests that children with movement difficulties who also have very slow processing speed may be most at risk for dysfunctions in timing-based movement skills and that slow processing speed may interfere with efficient operation of executive functions involved in interval timing skills.
We found that processing speed moderated the relation between movement skills and interval timing such that poorer movement skills most strongly predicted more variable interval timing in children with very slow processing speed.
Nine- to 11-year-old children (N = 103; 53 % male; 67 % White, 4 % Black, 5 % Asian, 3 % Hispanic, 9 % biracial/mixed identity, 12 % unknown) performed behavioral interval timing, executive functioning, and processing speed tasks, along with a movement skills assessment.
Transactional associations of health-related worries among Asian families: Evidence from six-wave longitudinal data during COVID-19.
Transactional associations of health-related worries among Asian families: Evidence from six-wave longitudinal data during COVID-19.
To address this gap, we conducted a six-wave longitudinal survey of 303 families in China.
During public health crises, family members often experience heightened health-related worry.
However, little is known about how the transactional processes of such worry operate within family systems involving mother, father, and their child.
Each month, mothers (Mage = 33.35 years) and fathers (Mage = 34.97 years) of children (Mage = 3.98 years, age range 2-7 years, 55.6 % male) reported their own and their perceptions of their child 's COVID-19-related health worries (e.g., infection concerns).
Chemical Insights into Interfacial Materials from Brazilian Crude Oils via Comparative Extraction Methods.
Model emulsion tests further showed that the IM fractions obtained by centrifugation/Dean-Stark conferred greater stability to the W/O system than those isolated using wet silica, indicating that emulsion stabilization depends on the combined action of polar and nonpolar species.
When Time Stands Behind the Patient: The Face, the Surgeon, and Goya's Old Women.
Most critically, in vivo wound healing studies in rats showed complete wound closure by day 16, significantly outperforming marketed formulations and controls.
Ex vivo permeation achieved 97.8 % cumulative permeation, attributed to the synergistic effects of menthol and propylene glycol.
In vitro release demonstrated sustained delivery over 8 h (86.7 ± 1.6 %), following Korsmeyer-Peppas kinetics indicative of anomalous diffusion.
This study establishes a stable, patient-compliant FFS that integrates QbD principles with robust experimental design, achieving enhanced topical delivery and therapeutic performance.
The CO-RUT (F1) formulation demonstrates strong translational potential as a novel wound-healing platform and provides a methodological framework for developing next-generation film-forming sprays.
Eye Movement Patterns Under Exposure to Spatial Disorientation Illusions During Simulated Flight.
Gaze metrics such as fixations, saccades (rapid gaze shift between two points), and visits were compared between subjects who experienced SD and those who did not.
Our results suggest that to mitigate visual illusions, there is a need for greater instrument panel focus, whereas to mitigate vestibular illusions, increased HUD engagement is needed, as opposed to the current instructions.ApplicationOur findings may inform training programs to enhance performance in high-risk SD flight profiles.
SD prevention is of great importance, as there is currently no objective tool to identify its occurrence.MethodEye movements of 45 participants (30 aircrew members, 15 cadets) were recorded using Tobii Pro Glasses 2 in a Gyro-IPT SD flight simulator.
In contrast, during vestibular illusions, participants who examined the head-up display (HUD) more frequently had a lower probability of SD occurrence.ConclusionMitigating SD requires distinct eye-movement strategies tailored to the illusion type.
ObjectiveTo identify eye movement patterns that are correlated with spatial disorientation (SD) events during flights in a flight simulator that induces SD.BackgroundSpatial Disorientation is one of the main causes for aviation mishaps.
Metabacillus harenarius sp. nov., an alginate lyase-producing bacterium, and reclassification of 'Bacillus weihaiensis'.
Patients rated their worst preoperative pain to 4.5 on a scale from 0 to 10, and worst pain intensity of 5.3 during the first three postoperative days.
This prospective observational study included 83 patients between 18 and 79 years undergoing primary outpatient CTR.
All patients filled in consent forms and a questionnaire that assessed demographics, comorbidities, pain and function, sleep quality and pain catastrophizing.
Postoperatively, 47 % of the patients experienced moderate pain and 32, 5 % reported severe pain in the three first days.
This factor may be useful as part of preoperative screening to identify patients at higher risk for more severe postoperative pain.
Chloroplast and mitochondrial genomes of Sphaerosorus coelastroides Pascher (Xanthophyceae) from Central Appalachia, Clinch River, Virginia, United States.
This report describes the isolation and culture of Sphaerosorus coelastroides from the plankton of a freshwater river in the central Appalachian mountain chain.
Chloroplasts were light green, and confocal fluorescence microscopy revealed three or more per cell.
This isolate was deposited into the UTEX Culture Collection of Algae, making it the only strain of this alga available for phycological study at this time.
Differential interference microscopic analysis of our isolate revealed cell sizes ranging from 10.2 to 19 μm in diameter occurring in groups of two to 32 cells with a mucilage layer that changed thickness depending upon the phase of the life cycle.
This alga was first observed in a dry freshwater riverbed in Central Europe in 1908 and, since then, has been included in Xanthophyceae surveys from nearly all continents with temperate climates.
Seaweed community dynamics on the Konkan coast: Implications of variation in environmental factors.
Taken together, these data suggest that COX-2-derived PGE2 enhances IL-17A production in γδ $ $ \gamma \delta $ $ T cells in an EP2/EP4 dependent manner during allergic lung inflammation.
Single cell RNA sequencing (scRNA-seq) identified, and qPCR confirmed, that γδ $ $ \gamma \delta $ $ T cells express only two PGE2 receptors (EP2 and EP4).