INoVA Hub

Definitions used

The INoVA uses entity recognition models to extract models and associated readouts (outcomes) from sentences in PubMed abstracts. The following definitions are used for these entities:

Model

The experimental setup (e.g. wound healing assay, Irwin test) used to measure an outcome, or the system in which an outcome is being measured (e.g. CACO-2 cells, the liver, ob/ob mice). The following model types are included: In vitro, in vivo, ex vivo, in silico and in chemico.

Readout

What is being measured in the model. Both quantitative measures and qualitative outcomes are being retrieved.

Searching and filtering

The INoVA hub uses free text searches as well as pre-defined filtering options to guide the user in retrieving relevant publications. The various options are described below. Multiple filters and/or free text searches can be used to define your search.

Free text search

Free text searches are available for the model name, readout and species. By typing in the name and clicking on "apply", a substring search is performed on all models and readouts in our platform. For species, a generative AI mapping has been performed on the sentence level. Therefore, the species has been inferred from the model and/or sentence. To correctly handle abbreviations, an attempt is made to map a search term on its full name if an abbreviation is being used, and vice versa, abbreviations of a full name are included when possible. Boolean queries are currently not supported in search.

Predefined filters

The models recognized have been mapped to model parameters whenever possible. This mapping has been performed by a generative AI model on a contextual level. This means that the whole sentence has been used to classify the models to the predefined parameters.

The model parameters can be used either to query the INoVA hub data, or to filter results. To use the filters, select a parameter from the pulldown menu and click the apply button. When multiple model parameters are used, the AND logic is being performed. The following model parameters are available:

System type, e.g. in vitro, in vivo, in silico
System format, e.g. bioengineered system, organism
Inducer type, e.g. chemical, diet, genetic engineering
Health domain, e.g. cardiovascular disease
Organ system, e.g. heart, liver

For the organ system parameter, two levels of granularity are offered. The second level offers a more detailed.

Please note that the model parameters are set independent from each other. The user is responsible for making meaningful intersections of the parameter values.

Dynamic data

The information available in the INoVA hub interface is updated daily and contains all PubMed abstract data from the year 2015 onwards.

Selection and Download

To select and download PMIDs for further analysis, tick the box of the publication and click the download button. The number of downloads is limited to a maximum of 100 records.

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	Title	Model(s)	Readout(s)	Pub. year	PMID
	Constitutive NF-kB Activation Is Amplified by VSV in Aggressive PC3 Prostate Cancer Cells That Resist Viral Oncolysis. Show snippets (2)	pc3 cells lncap cells	levels of both total and phosphorylated iκb-α levels of the nf-κb p65 protein subunit phosphorylated form	2026	41600832
Analysis of the upstream NF-κB inhibitor IκB-α revealed higher levels of both total and phosphorylated IκB-α in PC3 cells compared to LNCaP cells, indicating constitutive activation of the NF-κB pathway via an IκB-α-dependent mechanism.
Furthermore, PC3 cells displayed elevated levels of the NF-κB p65 protein subunit compared to LNCaP cells, with its phosphorylated form significantly increased upon VSV infection.
	Baboon endogenous retrovirus (ERV) envelope pseudotyped lentiviral vectors outperform human ERV lentivectors for transduction of T, B, NK and HSPCs. Show snippet	hematopoietic cells	transduction efficiencies	2026	41554900
Since HERV-W gp uses the same entry receptors, we compared transduction efficiencies for BaEV-LVs and HERV-W-LVs in hematopoietic cells.
	Alport Syndrome is a Partial Tubulointerstitial Disease of the Kidney. Show snippet	human tissues ptc cultures distal tubular apparatus	collagen α5 (iv)	2026	41531438
In situ hybridization on human tissues and protein detection of collagen α5 (IV) in PTC cultures clearly showed that the distal tubular apparatus predominantly produces collagen IV for the TBM.
	Cabozantinib induces NLRP3-CASP1-GSDMD-dependent pyroptosis in hepatocellular carcinoma. Show snippet	hcc cells mdscs	pyroptotic cell death	2026	41534776
We show that cabozantinib induces pyroptotic cell death in both HCC cells and MDSCs via the canonical NLRP3-CASP1-GSDMD pathway.
	Comparative analysis of BMP signaling in human ECFCs reveals vascular bed-dependent ALK2 expression. Show snippet	cb-ecfcs results pb-ecfcs	angiogenesis	2026	41603470
Evaluation of sprouting angiogenesis revealed that si-RNA-mediated silencing of ALK2 in CB-ECFCs results in hypersprouting, while si-RNA-mediated silencing of ALK3 leads to hypersprouting in PB-ECFCs.
	Anti-resonance in developmental signaling regulates cell fate decisions. Show snippet	hek293t cells h9 human embryonic stem cells	signal frequency downstream pathway activation	2026	41562431
By leveraging optogenetic control of the Wnt signaling pathway in both HEK293T cells and H9 human embryonic stem cells, we systematically map the relationship between signal frequency and downstream pathway activation.
	Cell-cycle-dependent repression of histone gene transcription by histone H4. Show snippet	transgenic histone gene reporter germline cells	histone synthesis	2026	41491041
Here, we use a transgenic histone gene reporter and RNA interference in Drosophila to identify canonical H4 histone as a unique repressor of histone synthesis during the G2 phase in germline cells.
	Validation of shear wave elastography for assessing myocardial fibrosis in patients with end-stage heart failure. Show snippet	hearts cardiac explants	septal shear wave velocities septal collagen volume fraction cvf	2026	41490714
Septal shear wave velocities were compared to septal collagen volume fraction (CVF) in explanted hearts.Mean septal CVF in cardiac explants was 17.1±7.6 %.
	The Leucine-mTOR-Autophagy Axis in Granulosa Cells Mediates Circadian Disruption-Induced Anovulation. Show snippet	granulosa cells gcs	continuous light-induced ovulation disorders	2026	41362744
Conclusions: These results suggest that the disruption of the leucine-mTOR-autophagy axis in granulosa cells (GCs) mediates continuous light-induced ovulation disorders.
	PFPeA exposure drives hepatoxicity and liver fibrosis via oxidative stress/Wnt5a-induced hepatocyte senescence. Show snippet	c57bl/6 j mice thle-2 cells	pfpea liver injury	2026	41529635
Our study investigated the specific role of cellular senescence in PFPeA induced liver injury and its underlying mechanisms in C57BL/6 J mice and THLE-2 cells.
	Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia. Show snippet	drosophila glia	selective autophagy fine-tunes stat92e activity	2026	41500791
Selective autophagy fine-tunes Stat92E activity by degrading Su (var) 2-10/PIAS in Drosophila glia.
	LH promotes testosterone synthesis in rooster leydig cells through YAP1/ACSL4/SOAT1 pathway. Show snippets (2)	leydig cells	lh-induced testosterone production testosterone synthesis	2026	41529502
In this study, we reveal a previously unrecognized YAP1-ACSL4 axis essential for LH-induced testosterone production by integrating transcriptomic profiling and functional studies in Leydig cells.
Testosterone synthesis in Leydig cells requires precise coordination between LH signaling and cholesterol metabolism, but the mechanisms underlying this regulation remain incompletely understood.
	Chronic Kidney Disease and Superimposed Acute Kidney Injury: Greater Impact of Acute Insults on Outcomes. Show snippet	ckd patients	risk factors	2026	41523706
However, the risk factors associated with outcomes of AKI in CKD patients have not been widely studied to date.
	Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment. Show snippet	tm3 cells limbal cells	expression	2026	41556506
LMX1B is emerging as a key transcription factor for normal mitochondrial function, and its expression is much higher in TM3 cells than other limbal cells.
	MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia. Show snippet	hair-follicle cells	mitochondrial homeostasis	2026	41571202
Importantly, our findings reveal a previously unrecognized aromatase-mitochondria cross-talk in hair-follicle cells, whereby CYP19A1-derived estrogens sustain mitochondrial homeostasis under androgenic stress.
	METTL1 interacts with XPO5 to modulate pre-miRNA export. Show snippet	hek293t cells	mettl1 interactome	2026	41591839
To map the METTL1 interactome in HEK293T cells, we employed APEX2-mediated proximity labeling coupled with LC-MS/MS analysis.
	Cidofovir induces antiviral immunity against Bombyx mori nucleopolyhedrovirus by modulating multiple immune pathways in silkworm. Show snippet	bmn cells silkworm tissues	relish, stat, and ago2 genes expression of antimicrobial peptides cec-a and cec-b	2026	41326100
Gene expression analysis demonstrated significant upregulation of Relish, STAT, and Ago2 genes in both BmN cells and silkworm tissues after Cidofovir treatment, along with increased expression of antimicrobial peptides Cec-A and Cec-B.
	Dual-functional fluorescent bio-sensor for detecting ONOO - and polarity for targeted-diagnosis of NAFLD in vivo fluorescence imaging. Show snippet	hepg2 cells	lds endogenous onoo	2026	41611412
On this basis, PTQ was effectively employed for targeted monitoring of LDs and detection of endogenous ONOO- in HepG2 cells.
	Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection. Show snippet	mdck cells		2026	41501381
Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection.
	COX-2 downregulation via G-quadruplex structure induction in the PTGS2-promoter region by mononuclear octahedral cobalt(III) Schiff base complex [CoL 3] in colorectal cancer cells. Show snippet	colorectal cancer cells	cox-2 downregulation g-quadruplex structure induction	2026	41581627
COX-2 downregulation via G-quadruplex structure induction in the PTGS2-promoter region by mononuclear octahedral cobalt (III) Schiff base complex [ CoL 3 ] in colorectal cancer cells.
	Methyl ester sulfonate suppresses leydig cell steroidogenesis by targeting the GATA2/TGF-β1/SMAD signaling axis. Show snippet	cell thermal shift assay-Western leydig cells lcs	pathway	2026	41621211
Mechanistically, we combined RNA sequencing, molecular docking, and cell thermal shift assay-Western blotting (CETSA-WB) to uncover a novel pathway in Leydig cells (LCs).
	The Anti-proliferative Effects of Anandamide and Oleamide in Glioblastoma Cell Lines Recruit Mitochondrial and PPAR-γ Receptor Modulation. Show snippet	c6 rg2 cells	mitochondrial membrane potential mitochondrial complex i activity	2026	41533230
AEA and ODA also reduced mitochondrial membrane potential in C6, but not in RG2 cells, while impairing mitochondrial Complex I activity in C6.
	HIF-1α/BNIP3-mediated mitophagy mitigates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation. Show snippet	sh-sy5y neuronal cells bv-2 microglia	cell-type specificity	2026	41620782
The cell-type specificity of the HIF-1α/BNIP3/mitophagy pathway was evaluated by comparative analysis in SH-SY5Y neuronal cells and BV-2 microglia.
	CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity. Show snippet	muscle tissue c2c12 cells	mtorc1 myogenesis	2026	41506264
Functionally, we demonstrate that CASTOR proteins are highly expressed in muscle tissue and, in C2C12 cells, they regulate mTORC1 and myogenesis in response to different arginine availability.
	Desmosome Assembly Regulates Apical-Basal Polarization and Nuclear Shape in Simple Epithelial Cells. Show snippet	mdck cells	morphology of the nucleus nuclear shape	2026	41550060
Furthermore, the morphology of the nucleus in MDCK cells appears to be regulated by proper desmosome assembly and subsequent keratin network formation, because depletion of DP as well as that of E-cad/Cdh6, Pg, or PKP2/3 results in an irregular nuclear shape.
	CYP1B1 Modulates Stress and Repair Pathways in Airway Cells Challenged by Wood Smoke Particles. Show snippet	hbec3-kt cells	endoplasmic reticulum stress ers cell cycle arrest cytotoxicity	2026	41581139
CYP1B1 inhibition in HBEC3-KT cells exacerbated endoplasmic reticulum stress (ERS), which promotes cell cycle arrest and cytotoxicity, while overexpression of CYP1B1 attenuated ERS.
	Biocompatibility of Nickel Ferrite Nanoparticles on Systemic and Testicular Cells. Show snippet	testicular cells	cellular apoptosis	2026	41585702
The rapid and extensive internalization of these nanoparticles within testicular cells may result in cellular apoptosis.
	Circular RNA circCSNK1G3 induces Leydig cells proliferation and promotes testosterone production through the miR-29b/IGF1 axis. Show snippet	leydig cells lcs	expression dynamics biological activities	2026	41548225
Nevertheless, the expression dynamics and biological activities of circRNAs in Leydig cells (LCs) are still not well understood.
	FGF12 induces aberrant mechanosignaling in aortic smooth muscle cells during thoracic aortic aneurysm formation in Marfan syndrome mice. Show snippets (2)	aortic smcs	aberrant mechanosignaling taa formation	2026	41540272
Collectively, these findings identify FGF12 as a critical regulator of aberrant mechanosignaling in aortic SMCs and a key contributor to TAA formation in MFS.
Here we identify fibroblast growth factor 12 (FGF12) as a novel mediator of aberrant mechanosignaling in aortic SMCs during TAA formation in MFS.
	SP1 as a negative regulator of ADAMTS-8 in colorectal cancer: Evidence from functional and molecular analyses. Show snippet	sw480 cells	proliferation migration adamts-1 and adamts-8 expressions	2026	41506596
Functional analyses demonstrated that SP1 overexpression in SW480 cells increased proliferation and migration; conversely, it significantly suppressed the ADAMTS-1 and ADAMTS-8 expressions.
	Erratum: MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4B DCAF13 E3 Ligase in Osteosarcoma Cells. Show snippet	osteosarcoma cells	ubiquitination of pten	2026	41552387
Erratum: MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4B DCAF13 E3 Ligase in Osteosarcoma Cells.
	Sex-Specific Downregulation of CDK5RAP3 Exacerbates ER Stress-Mediated Inflammation and Apoptosis in CCl 4-Induced Acute Liver Injury. Show snippet	mouse embryonic fibroblasts mefs in vitro	inflammatory and apoptotic responses	2026	41595493
In addition, CDK5RAP3 was conditionally deleted in mouse embryonic fibroblasts (MEFs) using 4-hydroxytamoxifen to assess its direct role in regulating inflammatory and apoptotic responses in vitro.
	[The role of monocytes in Hantaan virus-induced vascular endothelial injury using a co-culture model]. Show snippet	hek293 cells huvecs	htnv np expression	2026	41620963
Results Depletion of monocytes significantly increased HTNV NP expression in both HEK293 cells and HUVECs.
	Tardigrade Dsup: Interactions with DNA and protection of cells from oxidative stress. Show snippet	hek293t cells yeast enhanced cell survival mammalian and yeast cells	yeast enhanced cell survival oxidative stress	2026	41620827
Furthermore, Dsup expression in both HEK293T cells and yeast enhanced cell survival in the presence of hydrogen peroxide, suggesting that the presence of Dsup allows both mammalian and yeast cells to better cope with oxidative stress.
	Association Between Caffeine Intake and Mortality Among Patients with Chronic Kidney Disease: A Population-Based Study. Show snippet	ckd patients	mortality all-cause mortality mortality due to cardiovascular disease, cancer influenza or pneumonia	2026	41505074
Weighted COX regression analysis was used to explore the linear relationship between caffeine intake and mortality among CKD patients (including all-cause mortality, as well as mortality due to cardiovascular disease, cancer, cerebrovascular disease, nephropathy, and influenza or pneumonia).
	Network Pharmacology Analysis of Chinese Patent Medicine Zishen Yutai Pills Treating Recurrent Spontaneous Abortion and In Vitro Validation. Show snippet	tube formation assay human umbilical vein endothelial cells huvecs		2026	41572698
The tube formation assay was conducted in human umbilical vein endothelial cells (HUVECs) with the intervention of active constituents in ZYP.
	Submucosal dissection and debridement for migratory esophageal foreign body removal in an elderly patient with acute presentation: A case report. Show snippet	octogenarian patients	migratory efb infection acute dysphagic manifestations	2026	41578588
This preliminary experience highlights the potential utility of ESD for foreign body clearance alongside selective debridement in managing migratory EFB complicated by localized infection and acute dysphagic manifestations in octogenarian patients, thereby proposing a feasible nonsurgical alternative approach.
	Dysregulation of YTHDF2 promotes the over expression of interferon beta in anti-MDA5 antibody-positive dermatomyositis. Show snippet	pbmcs and monocytes from anti-mda5 + dm patients and hc	mrna and protein expression levels of ythdf2	2026	41580740
Quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and Western blotting were conducted to determine the mRNA and protein expression levels of YTHDF2 in PBMCs and monocytes from anti-MDA5+DM patients and HC.
	Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway. Show snippet	in vivo ovarian gcs	pcos phenotypes gc apoptosis ages accumulation inflammatory cytokines state of oxidative stress nf-κb nuclear translocation	2026	41578404
In vivo, BSTJF mirrored the RAGE inhibitor FPS-ZM1 's efficacy by ameliorating PCOS phenotypes through reducing GC apoptosis, attenuating AGEs accumulation, inflammatory cytokines and state of oxidative stress, normalizing carbohydrate metabolism and lipid homeostasis, and inhibiting AGEs-RAGE-NOX4 axis activation and NF-κB nuclear translocation in ovarian GCs.
	L-Borneolum Attenuates Ischemic Stroke Through Remodeling BBB Transporter Function via Regulating MFSD2A/Cav-1 Signaling Pathway. Show snippet	brain tissue hcmec/d3 cells	expression of major facilitator superfamily domain containing 2a (mfsd2a), caveolin-1 (cav-1), sterol regulatory element-binding protein 1 (srebp1)	2026	41594832
Finally, immunofluorescence, real-time fluorescent quantitative PCR (RT-qPCR) and western blot analyses were performed to detect the expression of Major Facilitator Superfamily Domain Containing 2A (MFSD2A), caveolin-1 (CAV-1), sterol regulatory element-binding protein 1 (SREBP1) in brain tissue and hCMEC/D3 cells.
	ATP6V0d2 alleviates acute liver injury via promoting hepatocyte autophagy. Show snippet	hepatocytes hcs liver tissues	differentially expressed genes degs atp6v0d2	2026	41604740
In this study, three liver injury datasets were analyzed to screen the differentially expressed genes (DEGs) and identify Atp6v0d2, which was initially downregulated, and then upregulated to slightly higher than normal levels in both hepatocytes (HCs) and liver tissues in carbon tetrachloride (CCl4) -induced acute liver injury, with the most significant downregulation observed 24 h after CCl4 injection.
	Bisphosphate nucleotidase 1 promotes progression and docetaxel resistance in triple-negative breast cancer via STUB1-mediated destabilization of LIMA1. Show snippet	bpnt1-overexpressing cells tnbc cells	bpnt1-driven emt and malignant phenotypes	2026	41540000
Notably, re-expression of LIMA1 in BPNT1-overexpressing cells partially attenuated BPNT1-driven EMT and malignant phenotypes of TNBC cells.
	Identification of Cepharanthine as a Potential Therapy of Acid Sphingomyelinase Deficiency by Reducing Cellular Sphingosylphosphorylcholine. Show snippet	asmd lymphoblasts smpd1-ko cells smpd1y496h fibroblasts	spc storage	2026	41342385
Finally, a reduction of SPC storage was verified in ASMD lymphoblasts, SMPD1-KO cells and SMPD1Y496H fibroblasts by CEP treatment.
	Structural elucidation of active arabinogalactans from Alisma plantago-aquatica and its protection against acetaminophen-induced acute liver injury. Show snippet	in vitro hepg2 cells	apap-induced injury levels of gsh, sod, and cat mda production	2026	41617288
In vitro experiments demonstrated that arabinogalactans mitigated APAP-induced injury in HepG2 cells by enhancing the levels of GSH, SOD, and CAT, while reducing MDA production.
	Centrosomal P4.1-associated protein is a novel regulator of ESCRT pathway function during endosome maturation. Show snippet	cpap-depleted cells	tsg101 recruitment to the endosomes rab5-to-rab7 conversion evt of egfr to mvb	2026	41630909
TSG101 recruitment to the endosomes, Rab5-to-Rab7 conversion, and EVT of EGFR to MVB in CPAP-depleted cells are restored by re-introduction of CPAP or overexpression of, but not endogenous, HRS.
	Cry2 prompts clock oscillation and temporomandibular joint homeostasis under mechanical loading. Show snippet	chondrocytes condyle explants	mechanical loading-sustained circadian oscillations cartilage homeostasis	2026	41490462
Finally, down-regulation of Cry2 in both chondrocytes and condyle explants attenuated mechanical loading-sustained circadian oscillations and cartilage homeostasis.
	The binding of the salvianolic acid A to the citrullinating enzyme PADI4 as a potential treatment for cancer. Show snippet	glioblastoma cells	intact ring1b enzyme	2026	41496341
The effect of SAA was shown to be cell-line-dependent, and its presence in glioblastoma cells hampered the binding between intact RING1B and the enzyme.
	Improving cardiovascular risk prediction in metabolic liver disease with a novel biomarker-enhanced model. Show snippet	regression model liver-ascvd+ model masld/mash patients	predictive accuracy of cardiovascular events	2026	41513461
This study aims to enhance the predictive accuracy of cardiovascular events in MASLD/MASH patients by developing a novel regression model, the LIVER-ASCVD+ model, which integrates traditional cardiovascular risk factors with liver biomarkers.
	TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry. Show snippet	cardiomyocytes cms	rho gtpases cell cycle progression	2026	41577381
In addition, YAP6SA interacts with scaffold protein MPDZ to regulate Rho GTPases and promote cell cycle progression in cardiomyocytes (CMs).
	Glia Regulate the Timing of Photoreceptor Differentiation in the Drosophila Visual System. Show snippet	sub-retinal glia	insulin-like peptides ilp3 key downstream targets	2026	41449879
Cell-type-specific knockdown, epistasis analysis, and transgene rescue indicate that insulin-like peptides ILP3 and ILP6 are key downstream targets of the EGFR pathway in sub-retinal glia.
	Improving Nonviral Gene Delivery by Activating Mechanosensing-Dependent Endocytic Pathways. Show snippet	hela cells hmyo	te of both plasmid dna (pdna)-and mrna (mrna)-carrying gold-standard branched polyethylenimine (bpei)-based complexes	2026	41502370
These mechanically induced cellular adaptations resulted in significantly enhanced TE of both plasmid DNA (pDNA) - and mRNA (mRNA) -carrying gold-standard branched polyethylenimine (bPEI) -based complexes in both HeLa cells and hMyo, compared to static conditions.
	DTX1-mediated degradation of TUBB3 in Kupffer cells mitigates hepatocellular carcinoma progression by regulating M1/M2 polarization. Show snippet	hcc tissues kupffer cells kcs	tubb3 m2 polarization of tam hcc progression	2026	41577987
TUBB3 is significantly augmented in HCC tissues, and the knockdown of TUBB3 in Kupffer cells (KCs) inhibits M2 polarization of TAM and hinders the HCC progression.
	Different responses to homocysteine in primary endothelial cells and immortalized endothelial cell line. Show snippet	primary endothelial cells huvec hybrid endothelial cell line ea. hy926	mechanisms responses	2026	41499764
The underlying mechanisms have been studied using primary endothelial cells (HUVEC) and hybrid endothelial cell line EA.hy926, and their responses to disrupting agents should be similar.
	The effects of hypoxia inducible factor-1α in myeloid cells and a high-salt diet in a mouse model of orthodontic tooth movement. Show snippet	myeloid cells	hif1α	2026	41572852
Low-oxygen and high-salt conditions can stabilize HIF1α in myeloid cells.
	Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes. Show snippet	glomerular podocytes	networks	2026	41520218
Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes.
	NRF2-CD36 Axis-Mediated Oleic Acid-Induced Milk Fat Production in Dairy Cow Mammary Epithelial Cells. Show snippet	mammary tissue	oa-driven milk fat synthesis	2026	41626863
This study elucidates the NRF2-CD36 axis as a regulator of OA-driven milk fat synthesis in mammary tissue, offering practical value for dairy industry nutritional strategies.
	Role of gonadal soma-derived growth factor (gsdf) on sex-differentiation in Nile tilapia, Oreochromis niloticus. Show snippet	body cavity of xx larvae undifferentiated gonads	effects on the expression of sex differentiation-related genes	2026	41534571
Furthermore, recombinant Gsdf (rGsdf) was produced and microinjected into the body cavity of XX larvae to investigate its effects on the expression of sex differentiation-related genes in undifferentiated gonads.
	Parthenolide Alleviates Peritoneal Fibrosis by Blocking Smad2/3 Phosphorylation via Smad Anchor for Receptor Activation. Show snippet	long-term-retained pd fluid samples pd mice tgf-β1-treated met-5a cells hmrsv5 cells	smad2/3 sara degradation sara expression fibrosis progression	2026	41546557
The results revealed that SARA activates Smad2/3, whereas Smad3 promotes SARA degradation, leading to the downregulation of SARA expression during fibrosis progression in long-term-retained PD fluid samples, PD mice, TGF-β1-treated MeT-5A cells, and HMrSV5 cells.
	Synthesis, Biological Evaluation, and Molecular Docking of Benzimidazole-hydrazone Derivatives as Potential Anticancer Agents Targeting Tyrosine Kinases: Induces G 0-G1 Phase Arrest in HepG2 Cells. Show snippet	hepg2 cells	g 0-g1 phase arrest	2026	41631797
Synthesis, Biological Evaluation, and Molecular Docking of Benzimidazole-hydrazone Derivatives as Potential Anticancer Agents Targeting Tyrosine Kinases: Induces G 0-G1 Phase Arrest in HepG2 Cells.
	Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome. Show snippet	fxs neurons	anaplerosis into the tca cycle bioenergetic and biosynthetic functions	2026	41557506
Metabolic tracing in FXS neurons demonstrates a dearth of glutamine deamidation to glutamate, which reduces anaplerosis into the TCA cycle, potentially hindering the bioenergetic and biosynthetic functions of mitochondria.
	Integrative analysis of proteomics and metabolomics reveals amino acid metabolism disorder in adriamycin-resistant acute myeloid leukemia cells. Show snippet	hl60/r cells	amino acid metabolism metabolic pathways of alanine, aspartate and glutamate, cysteine and methionine glutathione metabolism	2026	41513813
An integrative analysis of proteomic and metabolomic data revealed significant disruptions in amino acid metabolism in HL60/R cells, including the metabolic pathways of alanine, aspartate and glutamate, cysteine and methionine, as well as glutathione metabolism.
	Improved Prediction of Vancomycin Pharmacokinetics in Patients Receiving Continuous Renal Replacement Therapy Using a Novel Population Model Validated With Real-World Data. Show snippet	nonhemodialysis patients crrt patients	parameter estimates predictive performance	2026	41510782
Inclusion of nonhemodialysis patients in model development stabilized parameter estimates without affecting predictive performance in CRRT patients.
	Safety Assessment of Repeated Oral Administration of Tolfenamic Acid in Japanese Quails: Haematological, Biochemical and Histopathological Evaluations. Show snippet	japanese quails (coturnix coturnix japonica)	safety profile	2026	41495376
This study evaluated the safety profile of tolfenamic acid following repeated oral administration in Japanese quails (Coturnix coturnix japonica) at doses of 2 and 8 mg/kg every 12 h for 7 days.
	Transcriptional plasticity of stromal cells amplifies their differentiation efficiency in vitro. Show snippet	stromal cells in vitro	gene expression analysis	2026	41570986
In this study we performed gene expression analysis at bulk and single cell level in stromal cells being repeatedly exposed to osteogenic and adipogenic inducers in vitro.
	Intestinal Sclerostin Deficiency Links Gut Dysbiosis to Altered Serotonin Homeostasis in Axial Spondyloarthritis. Show snippet	healthy controls enterochromaffin cells	tph1 expression serotonin synthesis	2026	41518441
In healthy controls, sclerostin modulated TPH1 expression and serotonin synthesis in enterochromaffin cells.
	Factors influencing vaccination decisions in patients with inflammatory rheumatic and musculoskeletal disease: a qualitative approach. Show snippet	irmd patients		2026	41501901
The results underline the importance of coordinated communication and clear responsibilities in the vaccination process for iRMD patients.
	Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis. Show snippet	livers primary hepatocytes	cd36	2026	41576568
A significant upregulation of CD36 was observed in livers following ischemia-reperfusion (I/R) injury and in primary hepatocytes after hypoxia-reoxygenation (H/R).
	Chiral and Dual Drugs Combination Reduces Tumor-Associated Neutrophils-Induced T-Cell Immunoparalysis to Treat Epithelial Ovarian Cancer. Show snippet	ovarian cells	chiral baicalin and astragaloside absorption of different chirals	2026	41504490
Here, we report an optical method to detect chiral baicalin and astragaloside IV and also monitor the absorption of different chirals in ovarian cells.
	Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions. Show snippet	endothelial cells	circrna-mirna sponging interactions	2026	41564714
Next, we created circRNA-miRNA-mRNA networks and mechanistically investigated the top circRNA-miRNA sponging interactions in endothelial cells.
	Methylation changes of gallbladder DNA during the formation of gallstones. Show snippet	gallbladder tissues	genome-wide methylation changes key signaling pathways gene expression	2026	41498173
To investigate the genome-wide methylation changes in gallbladder tissues during gallstone formation, as well as alterations in key signaling pathways and associated gene expression.
	The Role of Aldosterone in Vascular Permeability in Diabetes. Show snippet	transwell system human dermal microvascular endothelial cells hmec-1	endothelial permeability	2026	41511372
Additionally, the effects of ALDO and EPL on endothelial permeability were evaluated in human dermal microvascular endothelial cells (HMEC-1) using a Transwell system.
	Lipid Dysregulation in Renal Cancer: Drivers of Tumor Growth and Determinants of Treatment-Induced Toxicity. Show snippet	ccrcc cells renal parenchymal cells	lipid droplet dynamics cholesteryl ester biology mitochondrial perturbations	2026	41513115
We examine lipid droplet dynamics, cholesteryl ester biology, and mitochondrial perturbations in ccRCC cells and renal parenchymal cells exposed to therapeutic stress.
	Yiqihuoxue Decoction on ischemic cerebrovascular disease after carotid artery stenting: A retrospective study. Show snippet	icvd patients	neurological function activities of daily living	2026	41517789
Adjunctive YQHXD may improve neurological function and activities of daily living in ICVD patients after CAS, with a favorable safety profile.
	Does surgical approach affect Hirschsprung-associated enterocolitis risk? A comparison between transanal Swenson-like and endorectal pull-throughs. Show snippet	hscr patients	albumin level	2026	41505435
Subsequently, multivariate analysis indicated that albumin level was significantly associated with the occurrence of HAEC in HSCR patients following TEPT (p = 0.047).
	Phosphoproteomics Identification of ERK-Dependent Activation of Rps6kb1 in Cardiac Hypertrophy. Show snippet	primary neonatal rat ventricular myocytes nrvms	rps6kb1	2026	41505219
By utilizing phosphoproteomics in primary neonatal rat ventricular myocytes (NRVMs), we revealed Rps6kb1 as one of most activated kinases under growth stimulation.
	Apheresis CD8 +CCR7+CD45RA- T-Cells as a Novel Biomarker Associated with CAR T-Cell Kinetics and Clinical Outcome. Show snippet	apheresis samples r/r lbcl patients	frequencies of cd8 + tcm cells strong car-t expansion superior clinical outcome	2026	41596518
Our data suggest that high frequencies of CD8+ TCM cells in apheresis samples may represent a promising pre-treatment biomarker associated with strong CAR-T expansion and superior clinical outcome in r/r LBCL patients following axi-cel.
	A Hyperkinetic-dependent redox-sensing mechanism operates specifically in dorsal fan-shaped body neurons to promote sleep. Show snippet	dfb neurons	sleep need metabolic state to neuronal excitability3,4,5	2026	41558467
Together, these observations suggest that changes in mitochondrial oxidation in dFB neurons convey sleep need by coupling metabolic state to neuronal excitability3,4,5.
	Risk stratification using inflammatory and metabolic biomarkers: A multi-cohort predictive study of mortality in atherosclerotic cardiovascular disease. Show snippet	ascvd patients	predictive role all-cause mortality	2026	41494613
This study aims to investigate the predictive role of combined SHR and NLR indicators for all-cause mortality in ASCVD patients and their clinical applicability.
	Lung retention, distribution and persistence of polymer particles in rats exposed via inhalation. Show snippet	mammalian tissue	lung retention bioavailability fate	2026	41547831
Knowing that toxicokinetics information is essential for accurate risk assessment and management, this research aimed to (1) evaluate different sample preparation and quantification methods for nanoplastics particles in mammalian tissue, and (2) investigate the lung retention, bioavailability and fate of these particles.
	The HTT1a protein initiates HTT aggregation in a knock-in mouse model of Huntington's disease. Show snippet	hdhq150 and hdhq150δi brains	htt aggregation soluble htt1a levels htt1a	2026	41622913
Immunohistochemical and homogeneous time resolved fluorescence analysis showed that HTT aggregation in both HdhQ150 and HdhQ150ΔI brains contained HTT1a, but the dramatic decrease in soluble HTT1a levels in HdhQ150ΔI brains delayed the appearance of aggregated HTT1a by several months.
	Circ_0075691 regulates lipid metabolism in granulosa cells by interacting with EIF4A3 to promote PTGS2 mRNA stability. Show snippet	granulosa cells	lipid metabolism ptgs2 mrna stability	2026	41605366
Circ_0075691 regulates lipid metabolism in granulosa cells by interacting with EIF4A3 to promote PTGS2 mRNA stability.
	Desmopressin Induces Mitochondrial Fragmentation and Dysfunction in Human U87 MG Glioma Cells via CaMKII-Drp1 Signaling Pathway. Show snippet	glioma cells	ddavp disrupts mitochondrial homeostasis mitochondrial dysfunction cell damage	2026	41527347
These findings reveal that dDAVP disrupts mitochondrial homeostasis in glioma cells through AVPR2-mediated CaMKII-dependent regulation of Drp1 activity, leading to mitochondrial dysfunction and cell damage.
	Functional Characterization of a De Novo SCN2A Mixed Variant Linked to Early Infantile Developmental and Epileptic Encephalopathy. Show snippet	hek293 cells	channel protein expression effects on its function na+ currents activation curve inactivation curve kinetics of inactivation	2026	41630925
The NaV1.2 A1659V variant did not affect channel protein expression while exhibiting significant effects on its function as shown by the reduced Na+ currents, a shift of the activation curve toward more negative potentials, a shift of the inactivation curve to more negative voltages, and slower kinetics of inactivation compared with native NaV1.2 in HEK293 cells.
	Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α-TRPV1 pathway. Show snippet	tracheal tissues nd7/23 sensory neuron-like cells	expression of trpv1 and hif1α	2026	41635485
Expression of TRPV1 and HIF1α was examined in tracheal tissues and ND7/23 sensory neuron-like cells using immunofluorescence and qPCR.
	Computational Resolution Enhancement of Mitochondria monitoring in Multiple Organs using Intravital Two-Photon Microscopy. Show snippet	hepatic cells	mitochondria	2026	41583505
We implemented a trained self-supervised denoising model to suppress background noise and improve signal intensity, ensuring a clearer visualization of the mitochondria in hepatic cells.
	Predicting Sepsis in Heart Failure Patients Supported by Left Ventricular Assist Devices: The Role of VE-Cadherin and ADAM10. Show snippet	lvad patients	efficacy sepsis	2026	41596215
We aim to evaluate the efficacy of VE-Cadherin and ADAM10 for predicting sepsis in LVAD patients.
	Impact of Dry Eye Disease and Lipid-Containing Artificial Tears on Keratometric Reproducibility and Intraocular Lens Calculation in Cataract Patients. Show snippet	cataract patients	reproducibility of keratometric measurements	2026	41597465
This study aimed to evaluate the impact of DED on the reproducibility of keratometric measurements and to assess the effect of a four-week treatment with lipid-containing artificial tears on these parameters in cataract patients.
	Questionnaire-based nationwide survey on the safety of azathioprine in Japanese patients with rheumatic diseases: a cross-sectional study. Show snippet	japanese patients		2026	41481525
Azathioprine (AZA) is an established treatment for rheumatic diseases, but real-world safety data in Japanese patients remain limited.
	Avenanthramide C From Oats Possibly Exerts Anti-Inflammatory Effects in Human Umbilical Vein Endothelial Cells. Show snippet	human umbilical vein endothelial cells huvecs	il-6 secretion	2026	41511062
In human umbilical vein endothelial cells (HUVECs), IS (≥50 µg/mL) increased IL-6 secretion, while Ave (≥10 µM) suppressed this effect.
	Depletion of CD25 + cells restores Th1, Th2 and Th17 responses and mitigates Eimeria maxima infection in chickens. Show snippet	pbmcs spleen	cd4+cd25+t cell proportions mrna levels of il-10, tgf-β and il-4	2026	41579595
The results revealed that E. maxima infection significantly increased CD4+CD25+T cell proportions in PBMCs and spleen, along with upregulated mRNA levels of IL-10, TGF-β and IL-4.
	BECN1-mediated autophagy activates the glycolytic pathway to promote lactate synthesis in Sertoli cells of Tibetan sheep. Show snippet	tibetan sheep testes sertoli cells scs	regulatory mechanism	2026	41570479
However, the role of BECN1 in Tibetan sheep testes and its regulatory mechanism in Sertoli cells (SCs) remain unclear.
	Deciphering stromal cell interactions in osteosarcoma highlights CDKN2A and MMP14 as novel diagnostic and therapeutic biomarkers. Show snippet	stromal cells	19 gene modules m15 m17 os pathways ossification extracellular matrix organization skeletal system development	2026	41593799
hdWGCNA analysis clustered 19 gene modules in stromal cells, among which modules M14, M15, and M17 were closely associated with OS and enriched in pathways, such as ossification, extracellular matrix organization, and skeletal system development.
	Myomaker and ether lipids cooperate to promote fusion-competent membrane states. Show snippet	myomaker-expressing cells	fusion cell surface exposure of phosphatidylethanolamine and phosphatidylserine plasma membrane lipid distribution	2026	41575859
Elevating ether lipids in Myomaker-expressing cells induces fusion, even without Myomerger, and correlates with cell surface exposure of phosphatidylethanolamine and phosphatidylserine, indicating a role for Myomaker in remodeling plasma membrane lipid distribution.
	Just a little prick: careful cell contacts enabled by ceramic nanostraws. Show snippet	thp-1 cells	membrane located ion channels	2026	41622290
Future applications of nanostraw arrays are the functionalization with silane coating to immobilize proteins and/or the analysis of membrane located ion channels in THP-1 cells by electrophysiology.
	Implementing Photodynamic Therapy to Activate the IFN-1 Pathway in Melanoma Cells: A Protocol for Inducing Immunogenic Cell Death and Enhancing Dendritic Cell Maturation. Show snippet	melanoma cells	dendritic cell maturation	2026	41028263
Implementing Photodynamic Therapy to Activate the IFN-1 Pathway in Melanoma Cells: A Protocol for Inducing Immunogenic Cell Death and Enhancing Dendritic Cell Maturation.
	NCOA7 promotes OSCC progression by inhibiting ROS-regulated ferroptosis. Show snippet	oscc cells	intracellular reactive oxygen species (ros) ferroptosis	2026	41493594
The effects of NCOA7 on intracellular reactive oxygen species (ROS) and ferroptosis in OSCC cells were investigated under the treatment of antioxidants N-Acetyl-L-cysteine (NAC), ferroptosis inhibitors deferoxamine mesylate (DFO) and ferrostatin-1 (Fer-1), and ferroptosis inducers erastin.
	Alterations in gene expression and DNA methylation in the bovine blastocyst in response to choline supplementation during culture†. Show snippet	heifer blood cells blastocysts	hypermethylation	2026	41553261
Twelve of these DMR exhibited a consistent trend of hypermethylation in both heifer blood cells and blastocysts, whereas two DMR consistently showed a trend toward hypomethylation.

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