INoVA Hub

Definitions used

The INoVA uses entity recognition models to extract models and associated readouts (outcomes) from sentences in PubMed abstracts. The following definitions are used for these entities:

Model

The experimental setup (e.g. wound healing assay, Irwin test) used to measure an outcome, or the system in which an outcome is being measured (e.g. CACO-2 cells, the liver, ob/ob mice). The following model types are included: In vitro, in vivo, ex vivo, in silico and in chemico.

Readout

What is being measured in the model. Both quantitative measures and qualitative outcomes are being retrieved.

Searching and filtering

The INoVA hub uses free text searches as well as pre-defined filtering options to guide the user in retrieving relevant publications. The various options are described below. Multiple filters and/or free text searches can be used to define your search.

Free text search

Free text searches are available for the model name, readout and species. By typing in the name and clicking on "apply", a substring search is performed on all models and readouts in our platform. For species, a generative AI mapping has been performed on the sentence level. Therefore, the species has been inferred from the model and/or sentence. To correctly handle abbreviations, an attempt is made to map a search term on its full name if an abbreviation is being used, and vice versa, abbreviations of a full name are included when possible. Boolean queries are currently not supported in search.

Predefined filters

The models recognized have been mapped to model parameters whenever possible. This mapping has been performed by a generative AI model on a contextual level. This means that the whole sentence has been used to classify the models to the predefined parameters.

The model parameters can be used either to query the INoVA hub data, or to filter results. To use the filters, select a parameter from the pulldown menu and click the apply button. When multiple model parameters are used, the AND logic is being performed. The following model parameters are available:

System type, e.g. in vitro, in vivo, in silico
System format, e.g. bioengineered system, organism
Inducer type, e.g. chemical, diet, genetic engineering
Health domain, e.g. cardiovascular disease
Organ system, e.g. heart, liver

For the organ system parameter, two levels of granularity are offered. The second level offers a more detailed.

Please note that the model parameters are set independent from each other. The user is responsible for making meaningful intersections of the parameter values.

Dynamic data

The information available in the INoVA hub interface is updated daily and contains all PubMed abstract data from the year 2015 onwards.

Selection and Download

To select and download PMIDs for further analysis, tick the box of the publication and click the download button. The number of downloads is limited to a maximum of 100 records.

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	Title	Model(s)	Readout(s)	Pub. year	PMID
	Rinsenoside Rg1 and its involvement in Hippo-YAP signaling pathway alleviating symptoms of depressive-like behavior. Show snippet	crs mice cort-treated cells	important neuroprotective role hippo-yap signaling pathway neuronal apoptosis synaptic plasticity	2025	40281108
In conclusion, chronic G-Rg1 played an important neuroprotective role in either CRS mice or Cort-treated cells associated with the inhibition of Hippo-YAP signaling pathway, which was the core part of decreasing neuronal apoptosis and enhancing synaptic plasticity.
	Constitutive NF-κB Activation is Amplified by VSV in Aggressive PC3 Prostate Cancer Cells that Resist Viral Oncolysis. Show snippet	pc3 cells lncap cells	levels of both total and phosphorylated iκb-α	2025	41040215
Analysis of the upstream NF-κB inhibitor IκB- α revealed higher levels of both total and phosphorylated IκB- α in PC3 cells compared to LNCaP cells, indicating constitutive activation of the NF-κB pathway via an IκB-α-dependent mechanism.
	Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma. Show snippet	gbm tissues hypoxia-cultured cells	hif1α hif2α expression igf1r expression	2025	40290443
Our study demonstrated that HIF1α and HIF2α were highly expressed in GBM tissues and hypoxia-cultured cells, and their expression positively correlated with IGF1R expression.
	Endoplasmic reticulum stress and steroidogenic dysfunction in Leydig cells: Molecular mechanisms of UPR-mediated testosterone regulation. Show snippets (2)	leydig cells	er stress signaling steroidogenic function	2025	41371596
A comprehensive literature review was conducted using recent findings from molecular, cellular, and animal studies focusing on ER stress signaling in Leydig cells.
This review aims to synthesize current evidence on how endoplasmic reticulum (ER) stress affects steroidogenic function in Leydig cells.
	Shuxuetong Injection inhibits pyroptosis in acute ischemic stroke via CD44/NLRP3/GSDMD signal. Show snippet	tmcao rats ogd/r cells	pyroptosis inflammation expression levels of gsdmd-n, nlrp3 and cd44	2025	40074097
SXT reduced pyroptosis and inflammation in tMCAO rats and OGD/R cells by decreasing the expression levels of GSDMD-N, NLRP3 and CD44.
	Carnosic acid attenuates ventilator-induced diaphragmatic dysfunction via activation of the Nrf2/HO-1 pathway. Show snippet	model group diaphragms of mv mice dxms-treated c2c12 cells	expression levels of nrf2, p-nrf2 and ho-1	2025	41275825
Compared with the model group, CA intervention significantly increased the expression levels of NRf2, p-Nrf2 and HO-1 in both the diaphragms of MV mice and DXMS-treated C2C12 cells.
	HSPG-binding peptide Pep19-2.5 is a potent inhibitor of HPV16 infection. Show snippet	hela cells hacat cells	half-maximal inhibitory concentration ic50 antiviral activity	2025	39807885
The half-maximal inhibitory concentration (IC50) was determined to be 116 nM in HeLa cells and 183 nM in HaCaT cells, highlighting its potent antiviral activity.
	Impact of the COVID-19 Pandemic on ACO Prevalence Among AECOPD Patients (2019-2023) and Clinical Characteristics by Blood Eosinophil Levels. Show snippet	aecopd patients	prevalence of aco type 2 inflammation	2025	40241798
The prevalence of ACO among AECOPD patients increased during the late pandemic period, possibly indicating a role for type 2 inflammation.
	CircMYO9A inhibits influenza A virus replication by dampening hemagglutinin cleavage via increasing SERPINE1/PAI-1 expression. Show snippet	wsn-infected cells	circrna transcription profiles circrnas involved in viral replication circular rna circmyo9a	2025	40314425
In this study, we screened the circRNA transcription profiles of WSN-infected cells to identify circRNAs involved in viral replication and identified a novel differentially expressed circular RNA, circMYO9A.
	ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism. Show snippet	prostate tissue ano7-expressing cells	metabolic pathways genes associated with the myc pathway and oxidative phosphorylation ( oxphos	2025	39923095
ANO7 expression resulted in the downregulation of metabolic pathways, particularly genes associated with the MYC pathway and oxidative phosphorylation (OXPHOS) in both prostate tissue and ANO7-expressing cells.
	MALAT1 modulates granulosa cells ferroptosis and apoptosis through PAK2 upregulation in polycystic ovary syndrome. Show snippet	granulosa cells gcs	ferroptosis-regulated role of malat1 potential modulatory mechanisms	2025	40742191
We investigated the ferroptosis-regulated role of MALAT1 and its potential modulatory mechanisms in granulosa cells (GCs).
	PU.1 and TGF-β signaling activate the cell-surface expression of CD103 in mast cells and dendritic cells: opposite roles of GATA2 in the expression of mucosal mast cell genes. Show snippet	bmmcs peritoneal mcs	itgae expression	2025	40905627
Spi1 KD suppressed Itgae expression even in the presence of TGF-β in BMMCs and peritoneal MCs, whereas Gata2 KD amplified the TGF-β-induced increase in Itgae expression.
	Correlation Between PIK3R1 Expression and Cell Growth in Human Breast Cancer Cell Line BT-474 and Clinical Outcomes. Show snippet	bt-474 cells	cell growth akt-mtor signaling	2025	39850525
We concluded that downregulated PIK3R1 in BT-474 cells resulted in an increased cell growth and upregulated AKT-mTOR signaling.
	The carotid body oxygen sensor. Show snippet	glomus cells		2025	40267624
The acute O2-sensing pathway in glomus cells could provide new targets for respiratory and cardiovascular pharmacology.
	Three Distinctive Diacylglycerol Acyltransferases (DGAT1, DGAT2, and DGAT3) from Perilla frutescens and Their Potential in Metabolic Engineering for Designed Oil Production. Show snippet	nicotiana tabacum chlamydomonas reinhardtii tobacco leaves and seeds algal cells	oil content accumulation of the target ufa-tag (la-, oa-, or ala-tag)	2025	40753501
Genetic modulation of each of these PfDGAT in Nicotiana tabacum and Chlamydomonas reinhardtii significantly increased the oil content and accumulation of the target UFA-TAG (LA-, OA-, or ALA-TAG) in tobacco leaves and seeds as well as algal cells.
	Synergistic mechanisms of Banxia Xiexin decoction in overcoming chemoresistance and enhancing chemosensitivity in colorectal cancer. Show snippet	sw620/5-fu cells	5-fu resistance cell death g2-phase cell cycle arrest p-gp protein expression and activity	2025	40581262
We demonstrated combining BXD and 5-FU therapy abolished 5-FU resistance in SW620/5-FU cells by triggering cell death, producing G2-phase cell cycle arrest, and lowering P-gp protein expression and activity.
	Quercetin mitigated LPS-induced PANoptosis in the bursa of Fabricius via the cGAS/STING signaling pathway in broilers. Show snippet	broiler bursal cells dt40 cells	lps-induced oxidative stress mitochondrial dynamics imbalance mitochondrial metabolic dysfunction	2025	41389541
Results demonstrated that QUE effectively mitigated LPS-induced oxidative stress, mitochondrial dynamics imbalance, and mitochondrial metabolic dysfunction in broiler bursal cells and DT40 cells.
	Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy. Show snippet	bronj-derived mscs in situ	ferroptosis mscs osteogenesis bone regeneration	2025	41074167
Mechanistically, we identified a miR-145-3p/IREB2 regulatory circuit that governs ferroptosis in BRONJ-derived MSCs; exosome-mediated delivery of miR-145-3p reinstated this axis, thereby reactivating the MSCs osteogenesis and driving in situ bone regeneration.
	FAdV-4 induces more severe inflammatory responses compared to FAdV-8b. Show snippet	cardiomyocytes cm cardiac fibroblasts cf	immune responses	2025	40803222
Following this, the two reference strains, FAdV-4 and FAdV-8b, were inoculated into cardiomyocytes (CM) and cardiac fibroblasts (CF) to assess their immune responses.
	Ion homeostasis and coordinated salt tolerance mechanisms in a barley (Hordeum vulgare L.)doubled haploid line. Show snippet	dh20 hua30 mesophyll cells	k+ efflux na+ and h+ efflux	2025	39806297
Notably, the K+ efflux in DH20 was significantly lower while the Na+ and H+ efflux was significantly higher than those in Hua30 under salt stress in mesophyll cells.
	Integrated spectroscopic and morphological analyses reveal cellular shifts in gene-silenced melanoma CSCs. Show snippet	melanoma cscs	cytoskeletal and biochemical remodelling	2025	40854961
These findings demonstrate that targeting critical regulatory pathways induces cytoskeletal and biochemical remodelling in melanoma CSCs, offering a multi-dimensional perspective on cellular plasticity.
	Epigenetic predictor of smoking status in buccal cells. Show snippet	buccal cells	smoking	2025	40441662
Finally, logistic regression was employed for variable selection and to derive a novel DNA methylation-based classifier for smoking in buccal cells.
	Isoferulic Acid Mitigates Acute Lung Injury Induced by Sepsis Through the Inhibition of JAK2. Show snippet	in vivo in vitro clp mice lps-exposed raw264. 7 cells	inflammatory factors tnf-α, il-6	2025	40485414
According to in vivo and in vitro experimental results, IFA down-regulated inflammatory factors TNF-α, IL-6, and IL-1β in CLP mice and LPS-exposed RAW264.7 cells.
	AURKA/PLK1/CDC25C Axis as a Novel Therapeutic Target in INI1-Deficient Epithelioid Sarcoma. Show snippet	va-es-bj cells	proliferation tumorigenicity expression of aurka and its downstream effectors activation of plk1 and cdc25c	2025	39789853
Notably, our findings showed that the reintroduction of INI1 in VA-ES-BJ cells significantly reduced proliferation, mitigated tumorigenicity, and negatively regulated the expression of AURKA and its downstream effectors, as well as the activation of PLK1 and CDC25C.
	Nuclear receptor FXR inhibits ferroptosis to alleviate hepatic ischemia-reperfusion injury by targeting GPX4 in a mouse model. Show snippet	wild-type mice fxr knockout mice aml12 cells	regulatory mechanism of fxr	2025	40742574
In this study, we explored the potential regulatory mechanism of FXR in HIRI by using wild-type mice, FXR knockout mice, and AML12 cells.
	Ginsenoside Rg1 Alleviates Hydrogen Peroxide-Induced Autophagy and Apoptosis in Ovarian Granulosa Cells. Show snippet	ovarian gcs	mitochondrial function	2025	40571901
However, the underlying mechanisms by which it regulates mitochondrial function in ovarian GCs remain unclear.
	Transcriptome-wide Mendelian randomisation exploring dynamic CD4+ T cell gene expression in colorectal cancer development. Show snippet	cd4+ t cells tissues	gene expression tissue-specific expression changes	2025	40321251
However, our sensitivity analysis revealed that the genetic proxies used to instrument gene expression in CD4+ T cells also act as eQTLs in other tissues, highlighting the challenges of using genetic proxies to instrument tissue-specific expression changes.
	RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation. Show snippet	rm-amkl cells	genes	2025	40060447
Frizzled genes are upregulated by RM and downregulated in RM-AMKL cells in response to METTL3 inhibition, providing an m6A-dependent explanation for their upregulation.
	Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKα2 and inducing mitochondrial dysfunction. Show snippet	cardiomyocytes	dcm	2025	40683882
In conclusion, this work identifies a direct regulatory DUB of AMPK and presents a OTUD1-AMPK axis in cardiomyocytes for driving DCM.
	Protective effect of luteinizing hormone on frozen-thawed ovarian follicles and granulosa cells. Show snippet	granulosa cells oocytes	expression of transforming growth factor (tgf-β) and its superfamily members	2025	39808671
In addition, LH treatment significantly boosted the expression of transforming growth factor (TGF-β) and its superfamily members in both granulosa cells and oocytes.
	PCYT2 overexpression induces mitochondrial damage and promotes apoptosis in hepatocellular carcinoma cells. Show snippet	l02 cells hepg2 cells	expression levels of pcyt2	2025	40434993
We compared the expression levels of PCYT2 in L02 cells and HepG2 cells.
	Regulation of Energy and Cholesterol Metabolisms During Fetal Leydig Cell Differentiation by DHH, PDGF, and Ad4BP/SF-1. Show snippet	metabolic activity assays interstitial cells flc progenitor cells	energy metabolism gene expression	2025	40878802
Through transcriptome analysis, CUT & RUN-seq, and metabolic activity assays, we demonstrated that DHH and PDGF rapidly activate energy metabolism in interstitial cells, involving the FLC progenitor cells, without altering gene expression.
	Single-Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage. Show snippet	fdm-treated db/db eyes muller cells	protective effects dr expression apoptotic and autophagic signaling pathways	2025	41190783
Knockdown of Nna1 in FDM-treated db/db eyes reverses the protective effects of myopia on DR. Transcriptomic profiling links reduced Nna1 expression to enhanced apoptotic and autophagic signaling pathways in Müller cells.
	Visualization of CYP3A4 expression at both mRNA and protein levels simultaneously at single cell resolution in various conditions using RNAscope combined with immunofluorescence. Show snippet	cyp3a4-positive cells heparg cells	dynamic changes	2025	40850094
CYP3A4-positive cells showed dynamic changes during growth and differentiation stages in HepaRG cells.
	Differential protective roles of c-Jun N-terminal kinase-2 in non-parenchymal liver cells and hepatocytes during cholestasis. Show snippet	hepatocytes npcs bm-derived cells	confers protection	2025	40681041
Besides in hepatocytes, JNK2 in NPCs - but not in BM-derived cells - confers protection during cholestasis.
	Macrophage Phospholipase D3 promotes atherosclerosis via exacerbating foam cell formation and inducing inflammatory responses. Show snippet	apoe^-/-mice thp-1-derived foam cells		2025	41245776
Validation was performed in ApoE^-/- mice and THP-1-derived foam cells by qRT-PCR and western blotting.
	Frog Skin Antimicrobial Peptide 3-13 and Its Analogs Alleviate Atherosclerosis Cholesterol Accumulation in Foam Cells via PPARγ Signaling Pathway. Show snippet	apoe-/-as mice thp-1-derived foam cells	therapeutic potential cholesterol metabolism	2025	41002435
This study investigated their therapeutic potential in ApoE-/- AS mice and THP-1-derived foam cells, focusing on the regulation of cholesterol metabolism.
	Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A's impact on ERα-mediated transcriptional bursting. Show snippet	bpa-treated cells cells treated with e2	tff1 gene similar burst initiation kinetics	2025	40678530
Our analysis showed that the TFF1 gene exhibited similar burst initiation kinetics in BPA-treated cells compared to cells treated with E2.
	Glycogen synthase is required for heat shock-mediated autophagy induction in neuronal cells. Show snippet	neuronal cells	level activation of gs autophagy	2025	39912200
We further demonstrate that heat shock transcription factor 1 regulates the level and activation of GS during heat shock and that GS is essential for the induction of autophagy during heat stress in neuronal cells.
	Hydrogen regulates the aryl hydrocarbon receptor, improving bronchopulmonary dysplasia in neonatal rats and RLE-6TN cells exposed to hyperoxia. Show snippet	neonatal rats rle-6tn cells	aryl hydrocarbon receptor bronchopulmonary dysplasia	2025	41332897
Hydrogen regulates the aryl hydrocarbon receptor, improving bronchopulmonary dysplasia in neonatal rats and RLE-6TN cells exposed to hyperoxia.
	Hollow mesoporous Prussian blue nanozymes alleviate doxorubicin-induced cardiotoxicity by restraining oxidative stress associated with Nrf2 signaling. Show snippet	cardiomyocytes	ph-responsive characteristics release of dox	2025	39933346
The results suggest that HmPB (DOX) exhibits pH-responsive characteristics and minimizes the release of DOX from within HmPB (DOX) in cardiomyocytes.
	PTEN regulation by miR-486-5p contributes to the amelioration of polycystic ovary syndrome. Show snippet	granulosa cells gcs		2025	41032041
This research intended to identify the genes related to PCOS (Polycystic ovary syndrome) and verify the regulatory function of miR-486-5p as well as its target PTEN in granulosa cells (GCs).
	MiR-218 Exhibits Anti-Leukemia Effects by Targeting CTNND2 in Primary Acute Erythroid Leukemia HEL Cells. Show snippet	hel cells	mapk signaling pathway potential functional pathway leukemogenesis	2025	40100342
In addition, MAPK signaling pathway was identified and validated as the potential functional pathway involved in leukemogenesis caused by miR-218 overexpression in HEL cells.
	The cytotoxic and hemolytic potential of karmitoxin from Karlodinium armiger and how it interacts with sterols. Show snippet	rtgill-w1 hcec-1ct cells	ec50	2025	40032439
A 3-h incubation returned an EC50 of 111 and 175 nM in RTgill-W1 and in HCEC-1CT cells, respectively.
	Hsa_circ_0020491 promotes polycystic ovary syndrome by interacting with IGF2BP2 through regulation of granular cell autophagy and mitochondrial dysfunction. Show snippet	granulosa cells gcs	pcos pathogenesis	2025	40739999
This study investigated the role of hsa_circ_0020491 in PCOS pathogenesis, focusing on granulosa cells (GCs).
	A deoxynucleoside triphosphate triphosphohydrolase promotes cell cycle progression in Caulobacter crescentus. Show snippet	cells	dna synthesis	2025	40454833
DNA synthesis requires an abundance of dNTPs, but elevated dNTP concentrations in nonreplicating cells delay entry into S phase.
	Development and Characterization of an Inducible Bacterial Artificial Chromosome System for Studying Lytic Replication and Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus. Show snippet	original kshv bac16 clone slk-ibac cells	kshv lytic replication	2025	40358030
Here, we developed a new KSHV BACmid, namely as iBAC, by replacing the EGFP with TET3G transactivator under EF1α promoter and inserted Tet response elements in the promoter of RTA in the original KSHV BAC16 clone and characterized KSHV lytic replication in SLK-iBAC cells.
	Lectin-Based Substrate Detection in Fabry Disease Using the Gb3-Binding Lectins StxB and LecA. Show snippet	primary fabry fibroblasts α-gal a knockout podocytes	sphingolipid metabolism	2025	40076891
In addition, sphingolipid metabolism was analyzed in primary Fabry fibroblasts and α-Gal A knockout podocytes using targeted tandem liquid chromatography-mass spectrometry.
	Optimizing multiomics sample preparation: comparative evaluation of extraction protocols for HepG2 cells. Show snippet	hepg2 cells interphase pellet	metabolites	2025	41258943
This study systematically compared two established protocols for the simultaneous extraction of metabolites, lipids, and proteins from HepG2 cells: (i) a biphasic extraction with subsequent overnight protein digestion from the interphase pellet, and (ii) a monophasic extraction involving on-bead protein digestion.
	Prevalence and Risk Factors of Arrhythmias in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Show snippet	aecopd patients	prevalence of arrhythmias	2025	40922983
The pooled prevalence of arrhythmias in AECOPD patients was 15 % (95 % CI: 12-18 %), with considerable heterogeneity (I² = 99.93 %).
	Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres. Show snippet	mb cells neurospheres	expression of myc tp53	2025	39851500
Importantly, the actions of VPA in MB cells and neurospheres include a reduction in the expression of MYC and an increase in TP53.
	A function of Spalt proteins in heterochromatin organization and maintenance of genomic DNA integrity. Show snippet	drosophila cells salivary glands	chromatin accessibility localization of chromosomes nucleus miss-expression of transposable elements	2025	40326666
Here we describe several consequences of loss of spalt function in Drosophila cells, including changes in chromatin accessibility, generation of DNA damage, alterations in the localization of chromosomes within the nucleus in the salivary glands and miss-expression of transposable elements.
	Long noncoding RNA MALAT1 can regulate proliferation and apoptosis of LPS-treated HK-2 cells via targeting miR-23a-3p through regulating ERK signaling. Show snippet	serum of the septic aki patients lps-treated cells	malat1	2025	40395909
We found that MALAT1 was markedly increased in serum of the septic AKI patients and LPS-treated cells.
	METTL3-mediated m 6A modification of pri-miR-93 promotes hepatocellular carcinoma progression via CDKN1A suppression. Show snippet	hepg2 cells		2025	40517665
Bioinformatics analysis of the GSE37001 dataset showed that silencing METTL3 in HepG2 cells suppressed cell cycle-related pathways.
	Resveratrol improves boar semen quality in summer months through modulation of the AGEs-RAGE signaling pathway in Leydig cells. Show snippet	leydig cells	boar semen quality ages-rage signaling pathway	2025	41014661
Resveratrol improves boar semen quality in summer months through modulation of the AGEs-RAGE signaling pathway in Leydig cells.
	Regulation and functional importance of human periodontal ligament mesenchymal stromal cells with various rates of CD146+ cells. Show snippet	hpdl-mscs	surface rate of cd146	2025	40123853
The surface rate of CD146 in hPDL-MSCs was stimulated by the treatment with interleukin-1β and tumor necrosis factor-α, and inhibited by the treatment with interferon-γ.
	Adherence to vaccination against SARS-CoV-2 and vaccine safety in patients with immunoglobulin G4-related disease. Show snippet	igg4-rd patients	rate and outcome of sars-cov-2 infection	2025	39849976
Additionally, to investigate the rate and outcome of SARS-CoV-2 infection in IgG4-RD patients.
	The role of ABI2 in modulating nuclear proteins: Therapeutic implications for NUP54 and NUP153 in TNBC. Show snippet	mda-mb-231 cell line abi2-overexpressing cells	gene expression	2025	39843146
This study used RNA sequencing (RNA-seq) to examine the gene expression in MDA-MB-231 cell line and ABI2-overexpressing cells.
	Bisphenol AF exposure induced synaptic plasticity and neurobehavioral impairments via triggering the ROS-mediated PERK-eIF2α-ATF4 signaling pathway in adolescent mice. Show snippet	mouse brain sh-sy5y cells	expression levels of the perk-eif2α-atf4 axis expression levels of creb-bdnf proteins	2025	40795421
NAC, a scavenger of ROS, markedly suppressed the expression levels of the PERK-eIF2α-ATF4 axis and restored the expression levels of CREB-BDNF proteins in both mouse brain and SH-SY5Y cells.
	Autophagy Regulates Müller Glial Cell Inflammatory Activation. Show snippet	muller cells	heterogeneous response states of activation	2025	40879296
Gene expression analysis revealed a heterogeneous response to LPS in Müller cells, revealing two states of activation.
	Ethanol extract of Periploca forrestii Schltr. and chlorogenic acid alleviate ischemic stroke by inhibiting TLR4-mediated neuroinflammation. Show snippet	mcao/r rats ogd/r-treated bv2 cells	pi3k-akt pathway nf-κb signaling	2025	40614585
Consistent with this result, EEHGT activated PI3K-Akt pathway and inhibited NF-κB signaling in both MCAO/R rats and OGD/R-treated BV2 cells.
	17β-Estradiol promotes LL37-induced rosacea-like skin inflammation via G protein-coupled estrogen receptor 30. Show snippet	rosacea lesions ll37-treated mice hacat cells	gpr30	2025	40670220
GPR30 was overexpressed in rosacea lesions, LL37-treated mice, and HaCaT cells, with TFAP2C potentially mediating this effect.
	ANA-12 Targets and Inhibits BDNF/TrkB Signaling to Alleviate Pain Behaviors in Rheumatoid Arthritis Mice. Show snippet	ra mice il-1β-induced cells	nlrc4 and aim2 inflammasomes	2025	40673956
Besides, ANA-12 treatment decreased NLRC4 and AIM2 inflammasomes both in RA mice and IL-1β-induced cells.
	The EGFR Pathway as a Potential Therapeutic Target for Modulation of Radiation-induced Liver Injury. Show snippet	lsecs hepatocytes liver cells	egfr radiation damage	2025	40194772
Hub proteins from protein-protein interaction (PPI) networks across all time points for both LSECs and hepatocytes highlighted EGFR as a top-ranked protein, indicating the potential role in mitigating radiation damage in liver cells.
	Dimethylmonothioarsinic Acid (DMMTA V) Induces NQO1 Expression Through Coordinated Activation of NRF2 and AHR Pathways. Show snippet	c57bl/6 mice hepa-1c1c7 cells		2025	40058744
This study investigates its influence on NAD (P) H: quinone oxidoreductase (NQO1) regulation in C57BL/6 mice and Hepa-1c1c7 cells.
	Characterization of endogenous SUMOylation sites by click chemistry-based proteomics. Show snippet	hek293t cells	962 endogenous sumoylation sites	2025	40522366
In total, we identified 962 endogenous SUMOylation sites in HEK293T cells under heat shock conditions, which showed good complementarity with previous studies.
	SETD6 mediates selective interaction and genomic occupancy of BRD4 and MITF in melanoma cells. Show snippet	melanoma cells	recruitment of brd4 and mitf different genomic loci	2025	40809945
This chromatin complex plays a pivotal role in selective recruitment of BRD4 and MITF to different genomic loci in melanoma cells.
	Blocking Fpr3 ameliorates osteoarthritis by inhibiting NLRP3-mediated chondrocyte pyroptosis. Show snippet	aclt-induced mouse models cartilage lps-treated chondrocytes	expression of fpr3 chondrogenic markers collagen-ii, sox9 catabolic factors mmp3 inflammatory cytokines il-1β il-18 nlrp3 inflammasome members nlrp3 asc	2025	40848578
We assessed the expression of Fpr3, chondrogenic markers (Collagen-II, SOX9, and Aggrecan), catabolic factors (MMP3, MMP13, and ADAMTS5), inflammatory cytokines (IL-1β, IL-18, and COX-2), and NLRP3 inflammasome members (NLRP3, ASC, Cleaved caspase1, and GSDMD-N) in cartilage from ACLT-induced mouse models and LPS-treated chondrocytes.
	Okanin Attenuates Mitochondrial Dysfunction and Apoptosis in UVA-Induced HaCaT Cells by Mitophagy Through SIRT3 Pathway. Show snippet	hacat cells and mice	protective effects sirt3/foxo3a/pink1/parkin signaling pathway	2025	41008947
Taken together, our results suggest the protective effects of okanin against UV radiation in both HaCaT cells and mice induced, at least in part, by regulating SIRT3/FOXO3a/PINK1/Parkin signaling pathway.
	Efficacy of combinatorial inhibition of Hedgehog and autophagy pathways on the survival of AML cell lines. Show snippet	molm-13 cells cmk cells	arrest at the g0/g1 phase	2025	40449363
Moreover, dual targeting of these pathways resulted in arrest at the G0/G1 phase in MOLM-13 cells but not in CMK cells.
	CRIP1 exacerbates osteoarthritis progression by recruiting UBE3A to induce the ubiquitination-mediated degradation of MFGE8. Show snippet	oa mouse cartilage il-1β-induced chondrocytes	mfge8 expression	2025	41067282
CRIP1 knockdown increased MFGE8 expression in OA mouse cartilage and IL-1β-induced chondrocytes.
	Cannabidiol alleviates methamphetamine-induced autophagy and oxidative stress by suppressing sigma 1 receptor expression. Show snippet	ht22 cells c57bl/6 j mice	meth-induced autophagy oxidative stress	2025	41314517
In this study, METH-induced autophagy and oxidative stress were replicated in both HT22 cells and C57BL/6 J mice.
	PURPL Represses Radiation-Induced Apoptosis to Promote Radioresistance in Cutaneous Melanoma by Direct Interfering With BID Cleavage. Show snippet	melanoma cells	radioresistance	2025	40229942
Transcriptomic sequencing highlights PURPL as one of the top upregulated long noncoding RNAs in response to ionizing radiation (IR) treatment in melanoma cells, suggesting its role in radioresistance.
	Phillyrin prevents calcium oxalate kidney stones through the PPARγ signaling pathway. Show snippet	kidney stone induced rats caox-exposed hk-2 cells	pparγ signaling pathway	2025	40826835
Phillyrin activated the PPARγ signaling pathway in kidney stone induced rats and CaOx-exposed HK-2 cells.
	Compromised PPARγ Mediated Impaired Placental Glucose Transport via the PI3K/AKT Signaling Pathway is Associated with FGR. Show snippet	trophoblast cells cellular membrane	translocation of glut3 and glut4 cellular glucose uptake and transport	2025	39909142
In summary, PPARγ in trophoblast cells orchestrates the translocation of GLUT3 and GLUT4 to the cellular membrane via the PI3K/AKT signaling pathway, thereby regulating cellular glucose uptake and transport.
	Systemic protection through enhanced immunity and antioxidant defenses in immune-primed Mytilus coruscus: insights from cell/tissue-specific analyses. Show snippet	hemocytes key tissues of marine mussels mytilus coruscus	potential protective effects systemic responses in survival immune functions antioxidant responses	2025	39938621
This study investigated the potential protective effects of immune priming in hemocytes and key tissues of marine mussels (Mytilus coruscus) which were repeatedly challenged with Vibrio alginolyticus, focusing on systemic responses in survival, immune functions and antioxidant responses.
	Trofinetide Improves Cognitive Function in APP/PS1 Mice by Suppressing Inflammation and Apoptosis. Show snippet	app/ps1 mice aβo-treated cells	cognitive function aβ pathology neuroinflammation apoptosis therapeutic potential	2025	41269410
This study provides the first evidence that trofinetide improves cognitive function and mitigates Aβ pathology, neuroinflammation, and apoptosis in APP/PS1 mice and AβO-treated cells, highlighting its therapeutic potential for AD.
	NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer. Show snippet	nrf2 reporter mice pdac cells	nrf2 or downstream gene induction	2025	41324572
Nrf2 or downstream gene induction was assessed in Nrf2 reporter mice or in PDAC cells following exposure to gemcitabine (Gem), 5-fluorouracil (5-FU) or the capecitabine (Cap) metabolite 5-Fluoro-5'-deoxyuridine (5'-DFUR).
	Effects of nedaplatin combined with paclitaxel liposomes or docetaxel on survival rate and biomarkers in patients with recurrent ovarian cancer. Show snippet	roc patients	comparable efficacy tumor and inflammatory markers adverse reactions	2025	40385012
The combination of nedaplatin with paclitaxel liposomes or docetaxel demonstrated comparable efficacy in ROC patients, effectively reducing tumor and inflammatory markers without increasing adverse reactions.
	Venetoclax synergizes with Wnt/β-catenin inhibitor C-82 in acute myeloid leukemia by increasing the degradation of Mcl-1 protein. Show snippet	aml patients molm13-r cells	expression of β-catenin	2025	40442688
We displayed that the expression of β-catenin abnormally upregulated in AML patients and MOLM13-R cells.
	PMAIP1 mediates endoplasmic reticulum stress in human dental pulp stem cells during pulpitis pathogenesis. Show snippet	pulpitis specimens lps-treated hdpscs	expression of bip and chop	2025	41013511
Significantly elevated expression of BiP and CHOP was observed in pulpitis specimens and LPS-treated hDPSCs.
	SHP1 and its downstream p38/SP1/PI3K/YAP/Notch-1 signaling in trophoblast cells suppressed the progression of Preeclampsia via inhibiting proliferation of SMCs. Show snippet	trophoblast cells	progression of preeclampsia proliferation of smcs	2025	40346122
SHP1 and its downstream p38/SP1/PI3K/YAP/Notch-1 signaling in trophoblast cells suppressed the progression of Preeclampsia via inhibiting proliferation of SMCs.
	Doxorubicin-induced phosphorylation of lamin A/C enhances DNMT1 and activates cardiomyocyte death via suppressing GATA-4 and Bcl-xL in rat heart. Show snippet	cardiomyoblasts hearts	cell death ps22 lamin a/c, dna methylation expression gata-4 and bcl-xl	2025	39864225
In conclusion, Dox exposure in cardiomyoblasts and hearts causes cell death by increasing the pS22 lamin A/C, DNA methylation and reducing the expression GATA-4 and Bcl-xL.
	Mechanical stimulation induces electrical coupling via TNTs through calcium-dependent mechanisms in C2C12 cells. Show snippet	hek cells a549 cells c2c12 cells	gap junction (gj)-mediated and tnt-mediated intercellular electrical coupling	2025	40532305
We assessed both gap junction (GJ) -mediated and TNT-mediated intercellular electrical coupling in HEK cells, A549 cells, and C2C12 cells.
	Epidemiologically Relevant Phthalate Mixture and Mono(2-ethyl-5-hydroxyhexyl) Phthalate Exposure Alter Cell Energy Metabolism in Primary Mouse Granulosa Cells. Show snippet	granulosa cells	cellular metabolism	2025	40324639
These data indicate that a monophthalate mixture as well as single monophthalate exposure alter cellular metabolism in granulosa cells.
	Dihydroxyacetone decreases the dATP pool, inducing replication stress and genomic instability in BEAS-2B cells. Show snippet	beas-2b cells	replication stress	2025	41173392
These data demonstrate that DHA-induced DNA damage and dATP pool depletion cause replication stress in BEAS-2B cells, providing new information DHA 's genotoxic mechanism.
	Deoxynivalenol induces global DNA hypomethylation by modulating the expression of miR-29b and DNA methylation regulators in HepG2 cells. Show snippet	hepg2 cells	global dna hypomethylation mir-29b expression dnmts, mbd2, and tet expression levels genomic instability cancer initiation and progression	2025	40749799
Together, these results indicate that DON induced global DNA hypomethylation in HepG2 cells by altering miR-29b expression as well as DNMTs, MBD2, and TET expression levels, and provide insight into the potential of DON, as a DNA hypomethylation inducer, to cause genomic instability and cancer initiation and progression.
	CdTe quantum dots induce apoptosis in RSC96 cells by disrupting calcium homeostasis and triggering subcellular structural dysfunction. Show snippet	rsc96 cells	endoplasmic reticulum stress mitochondrial impairment production of mtros mitochondrial membrane potential	2025	40527434
Exposure to CdTe QDs in RSC96 cells induced endoplasmic reticulum stress and mitochondrial impairment, characterized by enhanced production of mtROS and a notable reduction in mitochondrial membrane potential.
	Assessment of microplastic toxicity on blood-testis barrier using 3D cell spheroids. Show snippet	sertoli cells tm4	pathways related to endoplasmic reticulum stress endoplasmic reticulum stress	2025	40972371
Finally, we detected pathways related to endoplasmic reticulum stress in Sertoli cells (TM4), and revealed that exposure to MPS triggered endoplasmic reticulum stress in TM4S.
	Anti-resonance in developmental signaling regulates cell fate decisions. Show snippet	hek293t cells h9 human embryonic stem cells	signal frequency downstream pathway activation	2025	39990305
By leveraging optogenetic control of the Wnt signaling pathway in both HEK293T cells and H9 human embryonic stem cells, we systematically map the relationship between signal frequency and downstream pathway activation.
	Augmenter of liver regeneration alleviates lipid accumulation in MASLD through ATF3-CD36 axis. Show snippet	alr-tx cells shalr cells	mrna and protein expression of atf3 (activating transcription factor 3) cd36 expression	2025	41241174
Further, the mRNA and protein expression of ATF3 (Activating Transcription Factor 3) were found to substantially elevated and decreased in ALR-Tx cells and shALR cells respectively, and CD36 expression was induced after ATF3 was knock down.
	Antisense oligonucleotide-based switches for conditional translation of synthetic mRNA. Show snippet	rrl hek cells	complementarity dynamic range	2025	41210590
Alternatively, PMOs that exhibit higher complementarity for the trigRNA than for the mRNA reached a dynamic range of 86.4 in RRL and 1.79 in HEK cells.
	Transcriptome Analysis Reveals the Molecular Mechanism of Potentilla anserina L. Polysaccharides in Mitigating Zearalenone-Induced Oxidative Stress in Porcine Sertoli Cells. Show snippet	testicular scs	protective effects against zea-induced oxidative damage	2025	40298800
Our previous study found that Potentilla anserina L. polysaccharides (PAP-1b) exhibited protective effects against ZEA-induced oxidative damage in testicular SCs.
	NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development. Show snippet	vitiligo melanocytes	cleavage of pro-il-1β and gsdmd	2025	40935835
The persistent activation of NLRP3 in vitiligo melanocytes promotes the cleavage of pro-IL-1β and GSDMD.
	A fluorescent probe for detecting carboxylesterase level on investigating Chinese medicine water decoction efficacy. Show snippet	colorectal cells	carboxylesterase (ce) level	2025	40215850
In this work, a fluorescent probe ImPI-CE with the imidazo-pyridin-isovanillin sub-structure was developed and studied for monitoring the Carboxylesterase (CE) level in colorectal cells on evaluating the Chinese medicine water decoction efficacy.
	Lipid droplets deposition in perihematoma tissue is associated with neurological dysfunction after intracerebral hemorrhage. Show snippet	perihematoma tissue	lipid droplets deposition neurological dysfunction	2025	39976011
Lipid droplets deposition in perihematoma tissue is associated with neurological dysfunction after intracerebral hemorrhage.
	Antiviral Effects of Tecovirimat and Cellular Ultrastructural Changes in Human Bronchial Epithelial Cell Line Following Monkeypox Virus Infection. Show snippet	calu-3 cells	mitochondrial structural modifications with perinuclear relocation	2025	40141361
Our results highlighted an active replication of MPXV in Calu-3 cells linked to mitochondrial structural modifications with perinuclear relocation and the formation of cytoplasmic vacuoles.
	Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis. Show snippet	dlbcl cells topologically associating domains tads) in dlbcl	interaction between b compartments intra-tad inter-tad contacts	2025	39849544
At the compartment scale, the interaction between B compartments was strengthened in DLBCL cells, while topologically associating domains (TADs) in DLBCL had elevated intra-TAD and reduced inter-TAD contacts.
	TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy. Show snippet	hearts of diabetic mice hg-treated cardiomyocytes	expression levels of tradd	2025	39753984
We showed that the expression levels of TRADD were significantly increased in the hearts of diabetic mice and HG-treated cardiomyocytes.

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