INoVA Hub

Definitions used

The INoVA uses entity recognition models to extract models and associated readouts (outcomes) from sentences in PubMed abstracts. The following definitions are used for these entities:

Model

The experimental setup (e.g. wound healing assay, Irwin test) used to measure an outcome, or the system in which an outcome is being measured (e.g. CACO-2 cells, the liver, ob/ob mice). The following model types are included: In vitro, in vivo, ex vivo, in silico and in chemico.

Readout

What is being measured in the model. Both quantitative measures and qualitative outcomes are being retrieved.

Searching and filtering

The INoVA hub uses free text searches as well as pre-defined filtering options to guide the user in retrieving relevant publications. The various options are described below. Multiple filters and/or free text searches can be used to define your search.

Free text search

Free text searches are available for the model name, readout and species. By typing in the name and clicking on "apply", a substring search is performed on all models and readouts in our platform. For species, a generative AI mapping has been performed on the sentence level. Therefore, the species has been inferred from the model and/or sentence. To correctly handle abbreviations, an attempt is made to map a search term on its full name if an abbreviation is being used, and vice versa, abbreviations of a full name are included when possible. Boolean queries are currently not supported in search.

Predefined filters

The models recognized have been mapped to model parameters whenever possible. This mapping has been performed by a generative AI model on a contextual level. This means that the whole sentence has been used to classify the models to the predefined parameters.

The model parameters can be used either to query the INoVA hub data, or to filter results. To use the filters, select a parameter from the pulldown menu and click the apply button. When multiple model parameters are used, the AND logic is being performed. The following model parameters are available:

System type, e.g. in vitro, in vivo, in silico
System format, e.g. bioengineered system, organism
Inducer type, e.g. chemical, diet, genetic engineering
Health domain, e.g. cardiovascular disease
Organ system, e.g. heart, liver

For the organ system parameter, two levels of granularity are offered. The second level offers a more detailed.

Please note that the model parameters are set independent from each other. The user is responsible for making meaningful intersections of the parameter values.

Dynamic data

The information available in the INoVA hub interface is updated daily and contains all PubMed abstract data from the year 2015 onwards.

Selection and Download

To select and download PMIDs for further analysis, tick the box of the publication and click the download button. The number of downloads is limited to a maximum of 100 records.

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	Title	Model(s)	Readout(s)	Pub. year	PMID
	Constitutive NF-kB Activation Is Amplified by VSV in Aggressive PC3 Prostate Cancer Cells That Resist Viral Oncolysis. Show snippets (2)	pc3 cells lncap cells	levels of both total and phosphorylated iκb-α levels of the nf-κb p65 protein subunit phosphorylated form	2026	41600832
Analysis of the upstream NF-κB inhibitor IκB-α revealed higher levels of both total and phosphorylated IκB-α in PC3 cells compared to LNCaP cells, indicating constitutive activation of the NF-κB pathway via an IκB-α-dependent mechanism.
Furthermore, PC3 cells displayed elevated levels of the NF-κB p65 protein subunit compared to LNCaP cells, with its phosphorylated form significantly increased upon VSV infection.
	Timing-dependent anti-inflammatory effects of empagliflozin in monocyte-derived macrophages from post-myocardial infarct patients with type 2 diabetes. Show snippet	t2dm-ami patients patient-derived macrophages cells ex-vivo	nlrp3-related inflammatory and senescence pathways	2026	41680826
Early empagliflozin administration in T2DM-AMI patients was associated with modulation of NLRP3-related inflammatory and senescence pathways in patient-derived macrophages, benefits observed when cells were stimulated ex-vivo with an inflammatory stimulus.
	Baboon endogenous retrovirus (ERV) envelope pseudotyped lentiviral vectors outperform human ERV lentivectors for transduction of T, B, NK and HSPCs. Show snippet	hematopoietic cells	transduction efficiencies	2026	41554900
Since HERV-W gp uses the same entry receptors, we compared transduction efficiencies for BaEV-LVs and HERV-W-LVs in hematopoietic cells.
	Alport Syndrome is a Partial Tubulointerstitial Disease of the Kidney. Show snippet	human tissues ptc cultures distal tubular apparatus	collagen α5 (iv)	2026	41531438
In situ hybridization on human tissues and protein detection of collagen α5 (IV) in PTC cultures clearly showed that the distal tubular apparatus predominantly produces collagen IV for the TBM.
	Correlation between complement C3 level and abdominal aortic calcification in non-dialysis chronic kidney disease patients: a cross-sectional study. Show snippets (2)	ndd-ckd patients	association between c3 and vc vc	2026	41704684
Restricted cubic spline (RCS) analysis and logistic regression model were used to explore the association between C3 and VC in NDD-CKD patients.
Older age and history of underlying diseases (hypertension, hyperlipidemia) are independent risk factors for VC in NDD-CKD patients.
	Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe. Show snippet	bmp9-stimulated ecs	pericyte-driven vessel stabilization jagged1 upregulation	2026	41650956
Lfng also contributes to pericyte-driven vessel stabilization by mediating Jagged1 upregulation in Bmp9-stimulated ECs.
	Cabozantinib induces NLRP3-CASP1-GSDMD-dependent pyroptosis in hepatocellular carcinoma. Show snippet	hcc cells mdscs	pyroptotic cell death	2026	41534776
We show that cabozantinib induces pyroptotic cell death in both HCC cells and MDSCs via the canonical NLRP3-CASP1-GSDMD pathway.
	Comparative analysis of BMP signaling in human ECFCs reveals vascular bed-dependent ALK2 expression. Show snippet	cb-ecfcs results pb-ecfcs	angiogenesis	2026	41603470
Evaluation of sprouting angiogenesis revealed that si-RNA-mediated silencing of ALK2 in CB-ECFCs results in hypersprouting, while si-RNA-mediated silencing of ALK3 leads to hypersprouting in PB-ECFCs.
	Regional absorption of talinolol mediated by intestinal transporters: insights from PBPK modeling analysis. Show snippet	caco-2 cells	basolateral to apical permeability apical to basolateral permeability transport	2026	41756241
The basolateral to apical permeability of talinolol in Caco-2 cells decreased as the extracellular pH decreased at the donor side, but the apical to basolateral permeability did not significantly change, indicating that the transport of talinolol by P-gp is pH-dependent.
	Elevated alpha-fetoprotein affects the long-term prognosis after hepatectomy in patients with hepatitis B-related intrahepatic cholangiocarcinoma. Show snippet	hbv-icc patients	survival and recurrence outcomes prognostic stratification	2026	41656102
The study concludes that elevated serum AFP independently predicts adverse survival and recurrence outcomes in HBV-ICC patients after curative resection, and combining AFP with CA19-9 enhances prognostic stratification, supporting AFP as a practical biomarker for postoperative risk assessment.
	Anti-resonance in developmental signaling regulates cell fate decisions. Show snippet	hek293t cells h9 human embryonic stem cells	signal frequency downstream pathway activation	2026	41562431
By leveraging optogenetic control of the Wnt signaling pathway in both HEK293T cells and H9 human embryonic stem cells, we systematically map the relationship between signal frequency and downstream pathway activation.
	Glutathione S-transferase Mu 3 Mitigates alcohol-induced hepatic lipid dysregulation via PYGM suppression. Show snippet	primary hepatocytes of ald mice etoh-treated aml-12 cells in vivo in vitro	gstm3 expression hepatic lipid accumulation	2026	41724276
We found that GSTM3 expression was markedly upregulated in primary hepatocytes of ALD mice and EtOH-treated AML-12 cells, whereas GSTM3 deficiency significantly exacerbated hepatic lipid accumulation both in vivo and in vitro.
	The desmoglein 2 interactome in primary neonatal cardiomyocytes. Show snippet	cardiomyocytes	membrane recruitment	2026	41641743
We show that PKP2 is a dynamic protein whose membrane recruitment in cardiomyocytes is dependent on tension.
	Cell-cycle-dependent repression of histone gene transcription by histone H4. Show snippet	transgenic histone gene reporter germline cells	histone synthesis	2026	41491041
Here, we use a transgenic histone gene reporter and RNA interference in Drosophila to identify canonical H4 histone as a unique repressor of histone synthesis during the G2 phase in germline cells.
	Validation of shear wave elastography for assessing myocardial fibrosis in patients with end-stage heart failure. Show snippet	hearts cardiac explants	septal shear wave velocities septal collagen volume fraction cvf	2026	41490714
Septal shear wave velocities were compared to septal collagen volume fraction (CVF) in explanted hearts.Mean septal CVF in cardiac explants was 17.1±7.6 %.
	The Leucine-mTOR-Autophagy Axis in Granulosa Cells Mediates Circadian Disruption-Induced Anovulation. Show snippet	granulosa cells gcs	continuous light-induced ovulation disorders	2026	41362744
Conclusions: These results suggest that the disruption of the leucine-mTOR-autophagy axis in granulosa cells (GCs) mediates continuous light-induced ovulation disorders.
	Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA. Show snippet	induced neural progenitor cell-derived astrocytes iastrocytes) from c9orf72 als (c9-als) cases c9-iastrocytes	purine metabolism dysfunction enzyme adenosine deaminase (ada	2026	41752089
Our laboratory has previously identified purine metabolism dysfunction in induced neural progenitor cell-derived astrocytes (iAstrocytes) from C9orf72 ALS (C9-ALS) cases (C9-iAstrocytes), driven by loss of the enzyme adenosine deaminase (ADA).
	PFPeA exposure drives hepatoxicity and liver fibrosis via oxidative stress/Wnt5a-induced hepatocyte senescence. Show snippet	c57bl/6 j mice thle-2 cells	pfpea liver injury	2026	41529635
Our study investigated the specific role of cellular senescence in PFPeA induced liver injury and its underlying mechanisms in C57BL/6 J mice and THLE-2 cells.
	LZTR1 Loss Reduces Vimentin Expression and Motility in Hep3B Hepatocellular Carcinoma Cells. Show snippet	hep3b cells	emp-related molecular and phenotypic state tumor cell behavior	2026	41752002
Collectively, these findings define an EMP-related molecular and phenotypic state associated with LZTR1 deficiency in Hep3B cells, providing insight into how LZTR1 loss reshapes tumor cell behavior in HCC.
	Orphan G protein-coupled receptor GPR137 regulates ferroptosis by targeting the Wnt/β-catenin pathway in sonic hedgehog-medulloblastoma. Show snippet	gpr137-knockdown cells		2026	41674956
Rescue experiments were performed by overexpressing β-catenin in GPR137-knockdown cells.
	Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia. Show snippet	drosophila glia	selective autophagy fine-tunes stat92e activity	2026	41500791
Selective autophagy fine-tunes Stat92E activity by degrading Su (var) 2-10/PIAS in Drosophila glia.
	LH promotes testosterone synthesis in rooster leydig cells through YAP1/ACSL4/SOAT1 pathway. Show snippet	leydig cells	lh-induced testosterone production	2026	41529502
In this study, we reveal a previously unrecognized YAP1-ACSL4 axis essential for LH-induced testosterone production by integrating transcriptomic profiling and functional studies in Leydig cells.
	Gluteal adipose-derived stem cell exosomes promote macrophage polarization and cartilage regeneration in osteoarthritis via PTPRC modulation. Show snippet	in vitro in human chondrocytes fibroblast-like synoviocytes thp-1-derived macrophages	effects	2026	41740370
Their effects were evaluated in vitro in human chondrocytes, fibroblast-like synoviocytes, and THP-1-derived macrophages using proliferation, migration, immunofluorescence, Seahorse metabolic analysis, and RNA sequencing.
	Chronic Kidney Disease and Superimposed Acute Kidney Injury: Greater Impact of Acute Insults on Outcomes. Show snippet	ckd patients	risk factors	2026	41523706
However, the risk factors associated with outcomes of AKI in CKD patients have not been widely studied to date.
	Isorhynchophylline protects against ferroptosis in diabetic nephropathy by activating Nrf2. Show snippet	diabetic mice hg-induced hk-2 cells	irn treatment inhibited ferroptosis iron content mda levels gsh levels protein levels of fth-1, gpx4, and slc7a11 protein levels oftfr-1 and ncoa4	2026	41654348
IRN treatment inhibited ferroptosis in both diabetic mice and HG-induced HK-2 cells by reducing iron content and MDA levels, elevating GSH levels, upregulating the protein levels of FTH-1, GPX4, and SLC7A11, and downregulating the protein levels ofTFR-1 and NCOA4.
	YAP1 Enhances Mesenchymal-Type Gene Expression in Human Adrenergic-Type Neuroblastoma Cells. Show snippets (2)	neuroblastoma cells sk-n-as cells	mesenchymal expression state mesenchymal signature genes mesenchymal-associated transcription factors	2026	41681855
The YAP1-mediated plastic switch towards a mesenchymal expression state in neuroblastoma cells may provide the molecular basis for novel therapeutic avenues.
Continuously activating YAP1 in SK-N-AS cells upregulated mesenchymal signature genes and mesenchymal-associated transcription factors.
	Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment. Show snippet	tm3 cells limbal cells	expression	2026	41556506
LMX1B is emerging as a key transcription factor for normal mitochondrial function, and its expression is much higher in TM3 cells than other limbal cells.
	MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia. Show snippet	hair-follicle cells	mitochondrial homeostasis	2026	41571202
Importantly, our findings reveal a previously unrecognized aromatase-mitochondria cross-talk in hair-follicle cells, whereby CYP19A1-derived estrogens sustain mitochondrial homeostasis under androgenic stress.
	ARHGAP11A affects lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD) progression by regulating FAM83A. Show snippet	luad and paad cells	glycolysis proliferation apoptosis resistance cell-cycle progression migration invasion mitochondrial membrane potential	2026	41674985
Finally, the knock down of ARHGAP11A and FAM83A significantly affected the glycolysis, proliferation, apoptosis resistance, cell-cycle progression, migration, invasion, and mitochondrial membrane potential of LUAD and PAAD cells.
	METTL1 interacts with XPO5 to modulate pre-miRNA export. Show snippet	hek293t cells	mettl1 interactome	2026	41591839
To map the METTL1 interactome in HEK293T cells, we employed APEX2-mediated proximity labeling coupled with LC-MS/MS analysis.
	Prolyl-isomerase Pin1 drives platinum resistance by regulating Notch3 stability and function in ovarian cancer. Show snippet	hgsoc cells	activation of the pin1/notch3 axis platinum resistance	2026	41673759
Here, we demonstrated that carboplatin treatment of HGSOC cells promoted the activation of the Pin1/Notch3 axis, resulting in platinum resistance.
	Epigenetic Silencing of Primary Cilia Genes by PRAME and ETS2 in Melanoma Cells. Show snippets (2)	melanoma cells	prame expression primary cilia formation ciliogenesis ciliary loss	2026	41700497
We demonstrate an inverse correlation between PRAME expression and primary cilia formation in melanoma cells (R = -0.83, p = 0.042), and show that PRAME knockdown significantly promotes ciliogenesis, underscoring its role as a negative regulator.
Together, these findings suggest that PRAME and ETS2 cooperatively suppress ciliogenesis in melanoma cells, proposing a previously unrecognized epigenetic mechanism of ciliary loss.
	Cidofovir induces antiviral immunity against Bombyx mori nucleopolyhedrovirus by modulating multiple immune pathways in silkworm. Show snippet	bmn cells silkworm tissues	relish, stat, and ago2 genes expression of antimicrobial peptides cec-a and cec-b	2026	41326100
Gene expression analysis demonstrated significant upregulation of Relish, STAT, and Ago2 genes in both BmN cells and silkworm tissues after Cidofovir treatment, along with increased expression of antimicrobial peptides Cec-A and Cec-B.
	Taohong Siwu Decoction and its components regulate the M1/M2 polarization of macrophages to alleviate inflammatory injury in Sepsis via the RAGE. Show snippet	in vitro study results raw 264.7 cells bmdms	lps-mediated m1-type polarization	2026	41692111
According to our in vitro study results, AMY blocked RAGE activity to mitigate the LPS-mediated M1-type polarization in RAW 264.7 cells and BMDMs.
	Revisiting the Platelet-β-Cell Axis: Insights into How Platelet-Derived Mediators, Lipid Signaling, and DOC2B Pathways Converge to Drive β-Cell Dysfunction in Type 2 Diabetes. Show snippet	pancreatic islets	serotonin platelet factor oxidative and endoplasmic reticulum (er) stress	2026	41659295
Activated platelets release serotonin, platelet factor 4 (PF4), sphingosine-1-phosphate (S1P), and microvesicles that trigger oxidative and endoplasmic reticulum (ER) stress in pancreatic islets.
	Dual-functional fluorescent bio-sensor for detecting ONOO - and polarity for targeted-diagnosis of NAFLD in vivo fluorescence imaging. Show snippet	hepg2 cells	lds endogenous onoo	2026	41611412
On this basis, PTQ was effectively employed for targeted monitoring of LDs and detection of endogenous ONOO- in HepG2 cells.
	Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection. Show snippet	mdck cells		2026	41501381
Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection.
	COX-2 downregulation via G-quadruplex structure induction in the PTGS2-promoter region by mononuclear octahedral cobalt(III) Schiff base complex [CoL 3] in colorectal cancer cells. Show snippet	colorectal cancer cells	cox-2 downregulation g-quadruplex structure induction	2026	41581627
COX-2 downregulation via G-quadruplex structure induction in the PTGS2-promoter region by mononuclear octahedral cobalt (III) Schiff base complex [ CoL 3 ] in colorectal cancer cells.
	Inhibition of LRRK2 alleviates LPS-induced hippocampal pericyte loss and depressive-like behaviors through suppressing the RIPK1-mediated necroptosis pathway. Show snippet	hbvps and hippocampal tissues	interaction between lrrk2 and activated ripk1	2026	41740343
Immunoprecipitation of LRRK2 revealed that LPS treatment significantly increased the interaction between LRRK2 and activated RIPK1 in HBVPs and hippocampal tissues, and this interaction was abolished by the LRRK2 inhibitors.
	Roles of Catecholamines and Inflammation in Endothelial Dysfunction: a Study Using Takotsubo Syndrome Patient-specific hiPSC-ECs. Show snippet	hd-hipsc-ecs tts-hipsc-ecs	mincle expression pro-inflammatory cytokines il-6 il-1β il-4 protein expression	2026	41644936
Elevated Mincle expression and pro-inflammatory cytokines, including IL-6 and IL-1β, along with reduced IL-4 protein expression, were observed in both HD-hiPSC-ECs and TTS-hiPSC-ECs.
	Methyl ester sulfonate suppresses leydig cell steroidogenesis by targeting the GATA2/TGF-β1/SMAD signaling axis. Show snippet	cell thermal shift assay-Western leydig cells lcs	pathway	2026	41621211
Mechanistically, we combined RNA sequencing, molecular docking, and cell thermal shift assay-Western blotting (CETSA-WB) to uncover a novel pathway in Leydig cells (LCs).
	Differential inclusion formation of an aggregation-prone protein reveals differences in the proteostasis capacity of neuronal cell lines. Show snippet	nsc-34 cells neuro-2a cells	inclusions	2026	41713559
We observed a significantly greater propensity of FlucDM to form inclusions in NSC-34 cells compared to Neuro-2a cells.
	The Anti-proliferative Effects of Anandamide and Oleamide in Glioblastoma Cell Lines Recruit Mitochondrial and PPAR-γ Receptor Modulation. Show snippet	c6 rg2 cells	mitochondrial membrane potential mitochondrial complex i activity	2026	41533230
AEA and ODA also reduced mitochondrial membrane potential in C6, but not in RG2 cells, while impairing mitochondrial Complex I activity in C6.
	HIF-1α/BNIP3-mediated mitophagy mitigates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation. Show snippet	sh-sy5y neuronal cells bv-2 microglia	cell-type specificity	2026	41620782
The cell-type specificity of the HIF-1α/BNIP3/mitophagy pathway was evaluated by comparative analysis in SH-SY5Y neuronal cells and BV-2 microglia.
	Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR. Show snippet	cardiomyocytes	klf15 activity fetal reprogramming pathological gene expression metabolic homeostasis	2026	41771837
To restore KLF15 activity, we utilized CRISPR/nuclease-dead (d) Cas9-based transcriptional enhancement (CRISPRa) in cardiomyocytes, which effectively abolished fetal reprogramming by simultaneously suppressing pathological gene expression and restoring metabolic homeostasis under sustained stress conditions.
	Lapatinib Promotes Apoptosis in Hepatoma Cells by Regulating SPP1 Expression. Show snippet	hepg2 cells	spp1 expression ratio of bax/bcl2 apoptosis	2026	41664365
Western blotting analyses revealed that lapatinib treatment reduced SPP1 expression in HepG2 cells, increased the ratio of BAX/Bcl2, and triggered apoptosis in cells.
	CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity. Show snippet	muscle tissue c2c12 cells	mtorc1 myogenesis	2026	41506264
Functionally, we demonstrate that CASTOR proteins are highly expressed in muscle tissue and, in C2C12 cells, they regulate mTORC1 and myogenesis in response to different arginine availability.
	CRISPR/Cas9-based SLC12A3 gene knock in: a model for cellular feature analysis in Gitelman syndrome. Show snippet	kidney organoid cells wtc-11 and wtc-11slc12a3-ki groups	intracellular sodium flux	2026	41644267
The intracellular sodium flux was stimulated by angiotensin II treatment in kidney organoid cells and attenuated by thiazides in both WTC-11 and WTC-11SLC12A3-KI groups.
	Desmosome Assembly Regulates Apical-Basal Polarization and Nuclear Shape in Simple Epithelial Cells. Show snippet	mdck cells	morphology of the nucleus nuclear shape	2026	41550060
Furthermore, the morphology of the nucleus in MDCK cells appears to be regulated by proper desmosome assembly and subsequent keratin network formation, because depletion of DP as well as that of E-cad/Cdh6, Pg, or PKP2/3 results in an irregular nuclear shape.
	Comparative Analysis of Methamphetamine's Metabolic Effects on Blood-Brain Barrier Endothelial Cells: An In Vitro Recreational versus Addictive Simulation. Show snippet	bmvecs	transient metabolic dysfunction sdh activity δψm depolarisation intracellular ros production endothelial monolayer integrity	2026	41742624
Acute Meth caused transient metabolic dysfunction in BMVECs, marked by reduced SDH activity, ΔΨm depolarisation, and increased intracellular ROS production with subsequent metabolic recovery, however, endothelial monolayer integrity remained impaired long-term.
	Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders. Show snippet	in vivo pbmcs splenocytes	substantial btk degradation	2026	41727153
In vivo, a single administration of PSIRC3 leads to substantial BTK degradation in both PBMCs (> 80 %) and splenocytes (> 50 %).
	CYP1B1 Modulates Stress and Repair Pathways in Airway Cells Challenged by Wood Smoke Particles. Show snippet	hbec3-kt cells	endoplasmic reticulum stress ers cell cycle arrest cytotoxicity	2026	41581139
CYP1B1 inhibition in HBEC3-KT cells exacerbated endoplasmic reticulum stress (ERS), which promotes cell cycle arrest and cytotoxicity, while overexpression of CYP1B1 attenuated ERS.
	Biocompatibility of Nickel Ferrite Nanoparticles on Systemic and Testicular Cells. Show snippet	testicular cells	cellular apoptosis	2026	41585702
The rapid and extensive internalization of these nanoparticles within testicular cells may result in cellular apoptosis.
	A mixed-method process evaluation of guided online cognitive behavioral therapy for insomnia in patients with borderline personality disorder. Show snippet	bpd patients	underlying processes change mechanisms	2026	41680714
This study evaluated the key determinants, underlying processes, and change mechanisms of successful implementation of guided iCBT-I in BPD patients.
	PRIP/PLCL deficiency activates PI3K-AKT-YAP signaling and promotes organ fibrosis. Show snippet	in vitro experiments mouse embryonic fibroblasts mefs) from wt and prip-ko mice	prip/plcl-modulated signaling	2026	41680862
For in vitro experiments, we treated mouse embryonic fibroblasts (MEFs) from WT and Prip-KO mice with TGF-β1 (5 ng/ml) to verify PRIP/PLCL-modulated signaling in fibrosis using qPCR and western blotting.
	Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells. Show snippet	hek293t cells	rna-binding protein (rbp) binding sites transcriptome-wide binding sites of catalytically inactive pspcas13b (dpspcas13b) and rfxcas13d (drfxcas13d)	2026	41728952
In this study, we employed the uSpyCLIP method, which enhances sensitivity and specificity for identifying RNA-binding protein (RBP) binding sites, to map the transcriptome-wide binding sites of catalytically inactive PspCas13b (dPspCas13b) and RfxCas13d (dRfxCas13d) in HEK293T cells, using a variety of single guide RNAs (gRNAs).
	Circular RNA circCSNK1G3 induces Leydig cells proliferation and promotes testosterone production through the miR-29b/IGF1 axis. Show snippet	leydig cells lcs	expression dynamics biological activities	2026	41548225
Nevertheless, the expression dynamics and biological activities of circRNAs in Leydig cells (LCs) are still not well understood.
	Upregulation of the lncRNA MEG3 in Metastatic Hepatoblastoma. Show snippet	hlm_2 cells	clonogenicity migration invasion	2026	41744804
The effects of siRNA MEG3 knockdown in HLM_2 cells on clonogenicity, migration, and invasion were evaluated.
	Immunomediator expression in human periodontal ligament MSCs varies depending on surface CD146 expression. Show snippet	hpdl-mscs alters	immunomediator expression cd146 surface expression	2026	41724770
These results suggest that the immunomediator expression in hPDL-MSCs alters with different CD146 surface expression.
	Sensitive and Selective Next-Generation FRET-based PKA Biosensors. Show snippet	pc12 cells	strong gpcr-induced pka activities significant pka activity pka signaling	2026	41726949
Using the AKAR6 toolkit, we showed that in contrast to strong GPCR-induced PKA activities across all tested compartments in PC12 cells, growth factors stimulated a significant PKA activity at the trans-Golgi network but no detectable activity at cis-Golgi, signifying highly compartmentalized PKA signaling at the sub-organelle level.
	Chloroplast differentiation in epidermal cells: an environmental response supporting submerged photosynthesis in Rorippa aquatica. Show snippet	epidermal cells	chloroplast differentiation photosynthesis	2026	41701621
Chloroplast differentiation in epidermal cells: an environmental response supporting submerged photosynthesis in Rorippa aquatica.
	Single-cell transcriptomic atlas of glial cells in adult mouse dorsal root ganglia identifies multipotent progenitors. Show snippet	sgcs schwann cells	significant transcriptional heterogeneity repair and reactive sub-states	2026	41659411
High-resolution clustering resolved 26 cell types and demonstrated significant transcriptional heterogeneity within SGCs and Schwann cells, including repair and reactive sub-states.
	FGF12 induces aberrant mechanosignaling in aortic smooth muscle cells during thoracic aortic aneurysm formation in Marfan syndrome mice. Show snippets (2)	aortic smcs	aberrant mechanosignaling taa formation	2026	41540272
Collectively, these findings identify FGF12 as a critical regulator of aberrant mechanosignaling in aortic SMCs and a key contributor to TAA formation in MFS.
Here we identify fibroblast growth factor 12 (FGF12) as a novel mediator of aberrant mechanosignaling in aortic SMCs during TAA formation in MFS.
	SP1 as a negative regulator of ADAMTS-8 in colorectal cancer: Evidence from functional and molecular analyses. Show snippet	sw480 cells	proliferation migration adamts-1 and adamts-8 expressions	2026	41506596
Functional analyses demonstrated that SP1 overexpression in SW480 cells increased proliferation and migration; conversely, it significantly suppressed the ADAMTS-1 and ADAMTS-8 expressions.
	Safety and Tolerability of Nintedanib in Japanese Patients with Progressive Fibrosing Interstitial Lung Diseases: Final Results of 2-Year Post-Marketing Surveillance. Show snippet	japanese patients		2026	41718945
Existing clinical safety data for nintedanib treatment of PF-ILD in Japanese patients is based on relatively few patients, therefore, further evaluation is needed.
	LRP8 Promotes colorectal cancer progression by suppressing ferroptosis through the SLC3A2/GPX4 signalling axis. Show snippet	lrp8-depleted cells	glutathione peroxidase 4 (gpx4) expression oxidative stress ferroptosis resistance	2026	41639744
Reintroducing SLC3A2 in LRP8-depleted cells restored glutathione peroxidase 4 (GPX4) expression and mitigated oxidative stress, thereby rescuing ferroptosis resistance.
	Oridonin attenuates TLR4-driven inflammation and autophagy in LPS-stimulated enteric glial cells: an in vitro and in silico analysis. Show snippet	lps-stimulated egcs	tlr4-mediated inflammatory signaling and autophagy responses	2026	41684728
Here, we investigated the effects of oridonin on TLR4-mediated inflammatory signaling and autophagy responses in LPS-stimulated EGCs, with molecular docking used as a supportive, hypothesis-generating approach.
	Eugenol Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Senescence via Downregulation of Milk Fat Globule-EGF Factor 8. Show snippet	vsmcs vascular tissues	ang ii-induced aging mfg-e8 expression	2026	41674331
Eugenol prevents Ang II-induced aging in VSMCs and vascular tissues by downregulating MFG-E8 expression, underscoring its potential as an antiaging drug.
	Erratum: MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4B DCAF13 E3 Ligase in Osteosarcoma Cells. Show snippet	osteosarcoma cells	ubiquitination of pten	2026	41552387
Erratum: MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4B DCAF13 E3 Ligase in Osteosarcoma Cells.
	Sex-Specific Downregulation of CDK5RAP3 Exacerbates ER Stress-Mediated Inflammation and Apoptosis in CCl 4-Induced Acute Liver Injury. Show snippet	mouse embryonic fibroblasts mefs in vitro	inflammatory and apoptotic responses	2026	41595493
In addition, CDK5RAP3 was conditionally deleted in mouse embryonic fibroblasts (MEFs) using 4-hydroxytamoxifen to assess its direct role in regulating inflammatory and apoptotic responses in vitro.
	Exploring the protective mechanisms and therapeutic potential of carnosic acid against acute respiratory distress syndrome through molecular docking, molecular dynamics and experimental verification. Show snippet	in vitro mouse alveolar macrophages mh-s cells	pyroptosis oxidative stress lipopolysaccharide (lps)/atp	2026	41668995
In vitro studies were performed using mouse alveolar macrophages (MH-S cells) to examine the impact of CA on pyroptosis and oxidative stress triggered by lipopolysaccharide (LPS) /ATP.
	[The role of monocytes in Hantaan virus-induced vascular endothelial injury using a co-culture model]. Show snippet	hek293 cells huvecs	htnv np expression	2026	41620963
Results Depletion of monocytes significantly increased HTNV NP expression in both HEK293 cells and HUVECs.
	Mechanism study of LncRNA PRINS targeting TFAM to regulate mitochondrial dysfunction in human renal tubular epithelial cells under ischemia-reperfusion. Show snippet	aki patients h/r-induced hk-2 cells	expression of lncrna prins	2026	41662964
The expression of LncRNA PRINS was significantly upregulated in both AKI patients and H/R-induced HK-2 cells.
	Real-world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes: A multi-site retrospective study. Show snippet	japanese patients		2026	41674229
Despite the established efficacy of tirzepatide in randomised controlled trials, real-world effectiveness data in Japanese patients remain limited.
	Tardigrade Dsup: Interactions with DNA and protection of cells from oxidative stress. Show snippet	hek293t cells yeast enhanced cell survival mammalian and yeast cells	yeast enhanced cell survival oxidative stress	2026	41620827
Furthermore, Dsup expression in both HEK293T cells and yeast enhanced cell survival in the presence of hydrogen peroxide, suggesting that the presence of Dsup allows both mammalian and yeast cells to better cope with oxidative stress.
	Association Between Caffeine Intake and Mortality Among Patients with Chronic Kidney Disease: A Population-Based Study. Show snippet	ckd patients	mortality all-cause mortality mortality due to cardiovascular disease, cancer influenza or pneumonia	2026	41505074
Weighted COX regression analysis was used to explore the linear relationship between caffeine intake and mortality among CKD patients (including all-cause mortality, as well as mortality due to cardiovascular disease, cancer, cerebrovascular disease, nephropathy, and influenza or pneumonia).
	Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score as a Novel Biomarker for Predicting Coronary Slow Flow in Patients with Angina and/or Ischemia and Nonobstructive Coronary Arteries. Show snippet	anoca/inoca patients		2026	41682983
Its low cost and accessibility make it a promising tool for clinical risk stratification in ANOCA/INOCA patients, pending validation in multicenter prospective studies.
	Network Pharmacology Analysis of Chinese Patent Medicine Zishen Yutai Pills Treating Recurrent Spontaneous Abortion and In Vitro Validation. Show snippet	tube formation assay human umbilical vein endothelial cells huvecs		2026	41572698
The tube formation assay was conducted in human umbilical vein endothelial cells (HUVECs) with the intervention of active constituents in ZYP.
	Synergistic targeting of the ARID2-MYC axis by pomalidomide and panobinostat overcomes intrinsic IMiD resistance in multiple myeloma. Show snippet	myeloma cells	drug resistance	2026	41639146
Here, we elucidate the molecular basis of their synergy and its role in overcoming drug resistance in myeloma cells.
	Submucosal dissection and debridement for migratory esophageal foreign body removal in an elderly patient with acute presentation: A case report. Show snippet	octogenarian patients	migratory efb infection acute dysphagic manifestations	2026	41578588
This preliminary experience highlights the potential utility of ESD for foreign body clearance alongside selective debridement in managing migratory EFB complicated by localized infection and acute dysphagic manifestations in octogenarian patients, thereby proposing a feasible nonsurgical alternative approach.
	Real-world characterization of patients with advanced or metastatic liposarcoma, including dedifferentiated liposarcoma, in Japan in the MASTER KEY project. Show snippet	japanese patients	poor outcomes	2026	41636628
These data investigating DDLPS in Japanese patients highlight the poor outcomes and lack of effective treatment options in the real-world clinical practice setting.
	Dysregulation of YTHDF2 promotes the over expression of interferon beta in anti-MDA5 antibody-positive dermatomyositis. Show snippet	pbmcs and monocytes from anti-mda5 + dm patients and hc	mrna and protein expression levels of ythdf2	2026	41580740
Quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and Western blotting were conducted to determine the mRNA and protein expression levels of YTHDF2 in PBMCs and monocytes from anti-MDA5+DM patients and HC.
	Atg5-mediated autophagy modulation shapes the outcome of Bombyx mori Nucleopolyhedrovirus infection in silkworms. Show snippet	bmn cells larval tissues		2026	41692272
The temporal expression pattern of Atg5 showed a significant increase during the early infection stage (12-24 h) and a significant decrease at later stages (48-72 h) in both BmN cells and larval tissues.
	YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy. Show snippet	t2dm cardiomyocytes	protein nitration cardioprotective effects anxa3 expression	2026	41702019
Enhanced nitrosative stress in T2DM cardiomyocytes induces abnormal protein nitration, and while anti-nitration therapy demonstrates cardioprotective effects, the nitration-mediated regulation of ANXA3 expression requires elucidation.
	Protective Effect of Quercetin Against Nicotine-Induced Oxidative Stress and Granulosa Cell Apoptosis in Caprine Ovary In Vitro. Show snippet	ovarian tissue	total antioxidant capacity frap activity oxidative stress mda levels antioxidant properties	2026	41725258
Treatment with Qcn significantly increases the total antioxidant capacity (higher FRAP activity) and reduces oxidative stress (lower MDA levels) caused by NIC exposure in ovarian tissue, demonstrating Qcn 's antioxidant properties.
	Negative allosteric modulation of α5-GABA A receptors engages dynamic cortical glutamatergic and GABAergic mechanisms underlying adaptive behavior in mice. Show snippet	mpfc hippocampus	erk-or akt-mtor signaling pathways synaptic proteins critical for glutamatergic and gabaergic function	2026	41648568
In both mPFC and hippocampus, BSM rapidly activated Erk- or Akt-mTOR signaling pathways as well as increased synaptic proteins critical for glutamatergic and GABAergic function.
	Association Between Beta-Blocker Use and Outcomes in Patients with Sepsis-Induced Myocardial Injury: An Analysis Based on MIMIC-IV and eICU Databases. Show snippet	simi patients	mortality	2026	41651195
To evaluate beta-blocker impact on mortality in SIMI patients using MIMIC-IV and eICU databases.
	Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway. Show snippet	in vivo ovarian gcs	pcos phenotypes gc apoptosis ages accumulation inflammatory cytokines state of oxidative stress nf-κb nuclear translocation	2026	41578404
In vivo, BSTJF mirrored the RAGE inhibitor FPS-ZM1 's efficacy by ameliorating PCOS phenotypes through reducing GC apoptosis, attenuating AGEs accumulation, inflammatory cytokines and state of oxidative stress, normalizing carbohydrate metabolism and lipid homeostasis, and inhibiting AGEs-RAGE-NOX4 axis activation and NF-κB nuclear translocation in ovarian GCs.
	L-Borneolum Attenuates Ischemic Stroke Through Remodeling BBB Transporter Function via Regulating MFSD2A/Cav-1 Signaling Pathway. Show snippet	brain tissue hcmec/d3 cells	expression of major facilitator superfamily domain containing 2a (mfsd2a), caveolin-1 (cav-1), sterol regulatory element-binding protein 1 (srebp1)	2026	41594832
Finally, immunofluorescence, real-time fluorescent quantitative PCR (RT-qPCR) and western blot analyses were performed to detect the expression of Major Facilitator Superfamily Domain Containing 2A (MFSD2A), caveolin-1 (CAV-1), sterol regulatory element-binding protein 1 (SREBP1) in brain tissue and hCMEC/D3 cells.
	CT-based radiomics in predicting the efficacy of preoperative neoadjuvant chemoimmunotherapy for non-small cell lung cancer: a systematic review and meta-analysis. Show snippet	nsclc patients	neoadjuvant chemoimmunotherapy pathological response area under the curve auc sensitivity specificity	2026	41743740
Diagnostic accuracy of radiomics for detecting neoadjuvant chemoimmunotherapy pathological response in NSCLC patients was evaluated by calculating the area under the curve (AUC), sensitivity, specificity, and accuracy for each study.
	ATP6V0d2 alleviates acute liver injury via promoting hepatocyte autophagy. Show snippet	hepatocytes hcs liver tissues	differentially expressed genes degs atp6v0d2	2026	41604740
In this study, three liver injury datasets were analyzed to screen the differentially expressed genes (DEGs) and identify Atp6v0d2, which was initially downregulated, and then upregulated to slightly higher than normal levels in both hepatocytes (HCs) and liver tissues in carbon tetrachloride (CCl4) -induced acute liver injury, with the most significant downregulation observed 24 h after CCl4 injection.
	Bisphosphate nucleotidase 1 promotes progression and docetaxel resistance in triple-negative breast cancer via STUB1-mediated destabilization of LIMA1. Show snippet	bpnt1-overexpressing cells tnbc cells	bpnt1-driven emt and malignant phenotypes	2026	41540000
Notably, re-expression of LIMA1 in BPNT1-overexpressing cells partially attenuated BPNT1-driven EMT and malignant phenotypes of TNBC cells.
	Investigation of the Anticancer Effects and Senescence Induction of Hesperetin Combined with Cisplatin in Hepatocellular Carcinoma and Embryonic Fibroblast Cell Lines. Show snippet	hepg2 cancer cells nih-3t3 fibroblast cells	synergistic cytotoxic effects induction of senescence	2026	41660913
This study aimed to investigate the synergistic cytotoxic effects and selective induction of senescence by HST in combination with Cisp in HepG2 cancer cells and NIH-3T3 fibroblast cells.
	Regulation of ER-Resident Transcription Factor NFE2L1 in HEK293 Cells. Show snippet	hek293 cells		2026	41656087
Regulation of ER-Resident Transcription Factor NFE2L1 in HEK293 Cells.
	Fibrillin-1 is a novel ligand of the epidermal growth factor receptor promoting mesangial cell activation and glomerulosclerosis. Show snippet	mesangial cells	egfr phosphorylation of egfr	2026	41713647
RNA sequencing, molecular docking simulation and protein interactions analyses demonstrated that FBN1 could directly bind to EGFR in mesangial cells, which resulted in a sequential phosphorylation of EGFR, phosphoinositide 3-kinase (PI3K) and AKT kinase.

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